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Viruses. 2023 Jan 15;15(1):244. doi: 10.3390/v15010244.
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Influenza antivirals and their role in pandemic preparedness.流感抗病毒药物及其在大流行准备中的作用。
Antiviral Res. 2023 Feb;210:105499. doi: 10.1016/j.antiviral.2022.105499. Epub 2022 Dec 23.
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An optimized cell-based assay to assess influenza virus replication by measuring neuraminidase activity and its applications for virological surveillance.一种优化的基于细胞的检测方法，通过测量神经氨酸酶活性评估流感病毒复制及其在病毒学监测中的应用。
Antiviral Res. 2022 Dec;208:105457. doi: 10.1016/j.antiviral.2022.105457. Epub 2022 Nov 1.
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Host Range, Biology, and Species Specificity of Seven-Segmented Influenza Viruses-A Comparative Review on Influenza C and D.七节段流感病毒的宿主范围、生物学特性及种属特异性——关于丙型和丁型流感的比较综述
Pathogens. 2021 Dec 5;10(12):1583. doi: 10.3390/pathogens10121583.
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A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo.一种经过分子工程改造的抗病毒香蕉凝集素可抑制融合，对体内流感病毒感染具有疗效。
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C 型流感病毒对不同作用机制抗病毒药物的敏感性。

Influenza C virus susceptibility to antivirals with different mechanisms of action.

机构信息

Influenza Division, NCIRD, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.

ChemDiv, San Diego, California, USA.

出版信息

Antimicrob Agents Chemother. 2024 May 2;68(5):e0172723. doi: 10.1128/aac.01727-23. Epub 2024 Apr 8.

DOI:10.1128/aac.01727-23
PMID:38587392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11064526/
Abstract

Antiviral susceptibility of influenza viruses was assessed using a high-content imaging-based neutralization test. Cap-dependent endonuclease inhibitors, baloxavir and AV5116, were superior to AV5115 against type A viruses, and AV5116 was most effective against PA mutants tested. However, these three inhibitors displayed comparable activity (EC 8-22 nM) against type C viruses from six lineages. Banana lectin and a monoclonal antibody, YA3, targeting the hemagglutinin-esterase protein effectively neutralized some, but not all, type C viruses.

摘要

采用基于高内涵成像的中和试验评估了流感病毒的抗病毒敏感性。与 AV5115 相比，帽依赖性内切酶抑制剂 baloxavir 和 AV5116 对甲型病毒更有效，而 AV5116 对测试的 PA 突变体最有效。然而，这三种抑制剂对来自六个谱系的丙型病毒表现出相当的活性（EC8-22 nM）。针对血凝素-酯酶蛋白的香蕉凝集素和单克隆抗体 YA3 有效中和了一些，但不是所有的丙型病毒。