Li Xing, Yuan Xinyufei, Wu Yuting, Guo Honghong, Liu Qiang, Huang Shuangping
College of Biomedical Engineering, Taiyuan University of Technology, 79 West Yingze Street, Taiyuan 030024, People's Republic of China.
J Org Chem. 2024 Apr 19;89(8):5277-5286. doi: 10.1021/acs.joc.3c02637. Epub 2024 Apr 8.
A general and practical method for the construction of various 3,4,5-trisubstituted 1,2,4-triazoles via I-catalyzed cycloaddition of -functionalized amidines with hydrazones is reported. This strategy features cheap and readily available catalyst and starting materials, broader substrate scope, and moderate-to-good yields. The mechanism study shows that the existence of hydrogen on the nitrogen of hydrazones is crucial for this transformation.
报道了一种通过碘催化官能化脒与腙的环加成反应构建各种3,4,5-三取代-1,2,4-三唑的通用且实用的方法。该策略具有催化剂和起始原料廉价易得、底物范围更广以及产率中等至良好的特点。机理研究表明，腙氮上氢的存在对该转化至关重要。
