Department of General Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu, 610041, Sichuan, China.
Colorectal Cancer Center, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu, 610041, Sichuan, China.
Abdom Radiol (NY). 2024 Sep;49(9):3166-3174. doi: 10.1007/s00261-024-04266-z. Epub 2024 Apr 8.
This study aimed to compare the detection rates of Ga-FAPI-04 PET/CT and F-FDG PET/CT in colorectal cancer. A systematic search of major medical databases was conducted to identify studies up to September 2023. The primary outcome assessed was the detection rate of Ga-FAPI-04 PET/CT and F-FDG PET/CT in the primary tumor. Pooled risk ratios with a 95% CI were calculated using random-effect models to adjust for heterogeneity. Eight studies were included in the meta-analysis. Ga-FAPI-04 PET/CT has higher uptakes in lymph nodes, bone, and peritoneal metastasis compared with F-FDG PET/CT. The detection rate of Ga-FAPI-04 PET/CT based on lesion was better for lymph node metastasis (RR = 0.63, 95% CI 0.47-0.84, P = 0.002) and peritoneal metastasis (RR = 0.52, 95% CI 0.32-0.85, P = 0.009), both imaging modalities had essentially the same diagnostic efficacy in primary tumor (RR = 0.99, 95% CI 0.96-1.02, P = 0.49). Ga-FAPI-04 as a highly promising PET/CT tracer was superior to F-FDG PET/CT in colorectal cancer, especially in detecting lymph node metastases and peritoneal metastases.
本研究旨在比较 Ga-FAPI-04 PET/CT 和 F-FDG PET/CT 在结直肠癌中的检测率。通过系统检索主要医学数据库，截至 2023 年 9 月，共识别出 8 项研究。主要评估指标是 Ga-FAPI-04 PET/CT 和 F-FDG PET/CT 在原发性肿瘤中的检测率。采用随机效应模型计算合并风险比（RR）及其 95%置信区间（CI），以调整异质性。Ga-FAPI-04 PET/CT 在淋巴结、骨骼和腹膜转移灶中的摄取率高于 F-FDG PET/CT。基于病变的 Ga-FAPI-04 PET/CT 对淋巴结转移（RR=0.63，95%CI 0.47-0.84，P=0.002）和腹膜转移（RR=0.52，95%CI 0.32-0.85，P=0.009）的检测率更高，两种影像学方法在原发性肿瘤中的诊断效能基本相同（RR=0.99，95%CI 0.96-1.02，P=0.49）。Ga-FAPI-04 作为一种很有前途的 PET/CT 示踪剂，在结直肠癌中优于 F-FDG PET/CT，尤其在检测淋巴结转移和腹膜转移方面。
