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首个智能药丸:数字革命还是回光返照?

The First Smart Pill: Digital Revolution or Last Gasp?

出版信息

Kennedy Inst Ethics J. 2023;33(3):277-319. doi: 10.1353/ken.2023.a917930.

DOI:10.1353/ken.2023.a917930
Abstract

Abilify MyCite was granted regulatory approval in 2017, becoming the world's first "smart pill" that could digitally track whether patients had taken their medication. The new technology was introduced as one that had gained the support of patients and ethicists alike, and could contribute to solving the widespread and costly problem of patient nonadherence. Here, we offer an in-depth exploration of this narrative, through an examination of the origins and development of Abilify, the drug that would later become MyCite. This history illuminates how an antipsychotic can become a top-selling drug and maintain its blockbuster status for more than a decade. It also provides a detailed case study for how knowledge is constructed within the logic of biomedical capitalism, providing impetus to reexamine claims regarding how MyCite addresses patient nonadherence, engenders patient support, and is ethicist-approved.

摘要

阿立哌唑 MyCite 于 2017 年获得监管批准,成为世界上首款可数字化追踪患者是否服药的“智能药丸”。这项新技术被引入,是因为它得到了患者和伦理学家的一致支持,并可能有助于解决普遍且代价高昂的患者不依从性问题。在这里,我们通过考察后来成为 MyCite 的药物阿立哌唑的起源和发展,深入探讨了这一说法。这段历史阐明了一种抗精神病药物如何成为畅销药物,并保持十余年的畅销地位。它还为如何在生物医学资本主义逻辑内构建知识提供了一个详细的案例研究,促使人们重新审视关于 MyCite 如何解决患者不依从性、获得患者支持以及得到伦理学家认可的说法。

相似文献

1
The First Smart Pill: Digital Revolution or Last Gasp?首个智能药丸:数字革命还是回光返照?
Kennedy Inst Ethics J. 2023;33(3):277-319. doi: 10.1353/ken.2023.a917930.
2
Aripiprazole with digital ingestion tracking (Abilify MyCite).带有数字摄入追踪功能的阿立哌唑(阿立哌唑口服膜剂)
Med Lett Drugs Ther. 2019 Jan 28;61(1564):15-16.
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Digital aripiprazole or digital evergreening? A systematic review of the evidence and its dissemination in the scientific literature and in the media.数字阿立哌唑还是数字常青?对证据及其在科学文献和媒体中的传播的系统评价。
BMJ Evid Based Med. 2019 Dec;24(6):231-238. doi: 10.1136/bmjebm-2019-111204. Epub 2019 Jul 18.
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Abilify MyCite (Aripiprazole): A Critical Evaluation of the Novel Dosage Form.阿立哌唑口腔崩解片(阿立哌唑):新型剂型的批判性评价。
J Clin Psychopharmacol. 2021;41(1):93-94. doi: 10.1097/JCP.0000000000001334.
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Comments on Abilify MyCite.关于阿立哌唑口腔崩解片(阿立哌唑MyCite)的评论
Clin Schizophr Relat Psychoses. 2018 Jan;11(4):205-206. doi: 10.3371/CSRP.KA.010318.
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Letter to the Editor: Rethinking The Cost Of Antipsychotic Treatment: The Average Cost Of The Drugs Used In Turkey In 2020.给编辑的信:重新思考抗精神病药物治疗的成本:2020 年土耳其使用的药物的平均成本。
Turk Psikiyatri Derg. 2022 Summer;33(2):146-148. doi: 10.5080/u26315.
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Remote digital monitoring of medication intake: methodological, medical, ethical and legal reflections.远程数字化药物摄入监测:方法学、医学、伦理和法律方面的思考。
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Development of gummi drugs of aripiprazole as hospital formulations.阿立哌唑口嚼片作为医院制剂的研发。
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Aripiprazole (ABILIFY MAINTENA®): a review of its use as maintenance treatment for adult patients with schizophrenia.阿立哌唑(安律凡 MAINTENA®):作为成人精神分裂症患者维持治疗药物的使用评价。
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Lumateperone (Caplyta) for schizophrenia.用于治疗精神分裂症的鲁马西酮(Caplyta)。
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