Department of Pharmacology, Anadolu University, Graduate School of Education, Eskisehir, Turkey.
Department of Pharmacology, Afyonkarahisar Health Sciences, University Faculty of Pharmacy, Afyon, Turkey.
J Pharm Pharmacol. 2024 Jul 5;76(7):824-833. doi: 10.1093/jpp/rgae034.
We purposed to explore the consequences of the use quercetin and fisetin alone and in combination with pregabalin and gabapentin, which are used in the management of neuropathic pain, and on neuropathic pain in general. The anti-allodynic effect of various doses (5, 10, and 20 mg/kg) of quercetin and fisetin, both singly and in combination with pregabalin and gabapentin, was evaluated by developing a neuropathic pain model induced by chronic constrictive nerve damage in rats. The effectiveness of these flavonoids was investigated by combining them with gabapentin (50 mg/kg) and pregabalin (15 mg/kg), choosing the effectual dose of 10 mg/kg and the dose of 5 mg/kg, which did not show significant antiallodynic effects. In groups combined with gabapentin and pregabalin, it was determined that they showed a significant antiallodynic effect compared with 50 mg/kg gabapentin and 15 mg/kg pregabalin. In conclusion, in our combination studies, it was observed that the effectiveness of gabapentin and pregabalin, was increased and the duration of effect was prolonged when used with lower doses of flavonoids. Based on these findings; it is possible to say that quercetin and fisetin are potential agents that can be used alone or in combination with other effective treatments to alleviate neuropathic pain.
我们旨在探讨槲皮素和非瑟酮单独使用以及与普瑞巴林和加巴喷丁联合使用的后果，这些药物用于治疗神经性疼痛和一般的神经性疼痛。通过在大鼠中建立慢性缩窄性神经损伤诱导的神经性疼痛模型，评估了各种剂量（5、10 和 20 mg/kg）的槲皮素和非瑟酮单独使用以及与普瑞巴林和加巴喷丁联合使用的抗镇痛效果。通过将这些类黄酮与加巴喷丁（50 mg/kg）和普瑞巴林（15 mg/kg）联合使用，研究了它们的有效性，选择了有效剂量 10 mg/kg 和剂量 5 mg/kg，这两种剂量均未显示出明显的抗镇痛作用。在与加巴喷丁和普瑞巴林联合的组中，与 50 mg/kg 加巴喷丁和 15 mg/kg 普瑞巴林相比，它们显示出显著的抗镇痛作用。总之，在我们的联合研究中，当使用较低剂量的类黄酮时，加巴喷丁和普瑞巴林的有效性增加，作用持续时间延长。基于这些发现，可以说槲皮素和非瑟酮是单独使用或与其他有效治疗方法联合使用以缓解神经性疼痛的潜在药物。
