Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Victoria, Australia; Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore.
Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Victoria, Australia; Department of Surgery, St Vincent's Hospital, The University of Melbourne, Victoria, Australia.
Exp Gerontol. 2024 Jun 1;190:112421. doi: 10.1016/j.exger.2024.112421. Epub 2024 Apr 13.
Accelerated biological ageing is a major underlying mechanism of frailty development. This study aimed to investigate if the biological age measured by a blood biochemistry-based ageing clock is associated with frailty in geriatric rehabilitation inpatients.
Within the REStORing health of acutely unwell adulTs (RESORT) cohort, patients' biological age was measured by an ageing clock based on completed data of 30 routine blood test variables measured at rehabilitation admission. The delta of biological age minus chronological age (years) was calculated. Ordinal logistic regression and multinomial logistic regression were performed to evaluate the association of the delta of ages with frailty assessed by the Clinical Frailty Scale. Effect modification of Cumulative Illness Rating Scale (CIRS) score was tested.
A total of 1187 geriatric rehabilitation patients were included (median age: 83.4 years, IQR: 77.7-88.5; 57.4 % female). The biochemistry-based biological age was strongly correlated with chronological age (Spearman r = 0.883). After adjustment for age, sex and primary reasons for acute admission, higher biological age (per 1 year higher in delta of ages) was associated with more severe frailty at admission (OR: 1.053, 95 % CI:1.012-1.096) in patients who had a CIRS score of <12 not in patients with a CIRS score >12. The delta of ages was not associated with frailty change from admission to discharge. The specific frailty manifestations as cardiac, hematological, respiratory, renal, and endocrine conditions were associated with higher biological age.
Higher biological age was associated with severe frailty in geriatric rehabilitation inpatients with less comorbidity burden.
加速的生物学衰老（accelerated biological ageing）是衰弱（frailty）发展的主要潜在机制。本研究旨在探讨通过基于血液生化的衰老时钟（a blood biochemistry-based ageing clock）测量的生物学年龄（biological age）是否与老年康复住院患者的衰弱有关。
在 REStORing health of acutely unwell adulTs（RESORT）队列中，通过在康复入院时测量的 30 项常规血液检测变量的完成数据，基于衰老时钟来测量患者的生物学年龄。计算生物学年龄与实际年龄（chronological age）之间的差值（delta）。采用有序逻辑回归和多项逻辑回归来评估年龄差值与通过临床虚弱量表（Clinical Frailty Scale）评估的虚弱之间的关联。还测试了累积疾病评分量表（Cumulative Illness Rating Scale，CIRS）评分的效应修饰作用。
共纳入 1187 名老年康复患者（中位年龄：83.4 岁，IQR：77.7-88.5；57.4%为女性）。基于生化的生物学年龄与实际年龄高度相关（Spearman r=0.883）。在调整年龄、性别和急性入院的主要原因后，较高的生物学年龄（年龄差值每增加 1 岁）与入院时更严重的虚弱相关（OR：1.053，95%CI：1.012-1.096），在 CIRS 评分<12 的患者中，而在 CIRS 评分>12 的患者中则不然。入院到出院期间，年龄差值与虚弱变化无关。特定的虚弱表现，如心脏、血液、呼吸、肾脏和内分泌疾病，与较高的生物学年龄有关。
在合并症负担较轻的老年康复住院患者中，较高的生物学年龄与严重虚弱有关。
