Zhou Yinxue, Ren Dunqiang, Bi Huanhuan, Yi Bingqian, Zhang Cai, Wang Hongmei, Sun Jiaxing
Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
School of Medicine, Qingdao University, Qingdao 266000, China.
Zhongguo Fei Ai Za Zhi. 2024 Mar 20;27(3):231-240. doi: 10.3779/j.issn.1009-3419.2024.102.13.
Tumor-associated macrophage (TAM) play a crucial role in the immune microenvironment of lung cancer. Through changes in their phenotype and phagocytic functions, TAM contribute to the initiation and progression of lung cancer. By promoting the formation of an immune-suppressive microenvironment and accelerating the growth of abnormal tumor vasculature, TAM facilitate the invasion and metastasis of lung cancer. Macrophages can polarize into different subtypes with distinct functions and characteristics in response to various stimuli, categorized as anti-tumor M1 and pro-tumor M2 types. In tumor tissues, TAM typically polarize into the alternatively activated M2 phenotype, exhibiting inhibitory effects on tumor immunity. This article reviews the role of anti-angiogenic drugs in modulating TAM phenotypes, highlighting their potential to reprogram M2-type TAM into an anti-tumor M1 phenotype. Additionally, the functional alterations of TAM play a significant role in anti-angiogenic therapy and immunotherapy strategies. In summary, the regulation of TAM polarization and function opens up new avenues for lung cancer treatment and may serve as a novel target for modulating the immune microenvironment of tumors. .
肿瘤相关巨噬细胞（TAM）在肺癌免疫微环境中发挥着关键作用。通过其表型和吞噬功能的改变，TAM促进肺癌的发生和发展。通过促进免疫抑制微环境的形成和加速异常肿瘤血管的生长，TAM促进肺癌的侵袭和转移。巨噬细胞可根据不同刺激极化成为具有不同功能和特征的不同亚型，分为抗肿瘤M1型和促肿瘤M2型。在肿瘤组织中，TAM通常极化为交替激活的M2表型，对肿瘤免疫表现出抑制作用。本文综述了抗血管生成药物在调节TAM表型中的作用，强调了它们将M2型TAM重编程为抗肿瘤M1表型的潜力。此外，TAM的功能改变在抗血管生成治疗和免疫治疗策略中发挥着重要作用。总之，TAM极化和功能的调节为肺癌治疗开辟了新途径，并可能成为调节肿瘤免疫微环境的新靶点。
