Ren Y F, Otter G M, Schmid F A
Eur J Cancer Clin Oncol. 1985 Apr;21(4):493-7. doi: 10.1016/0277-5379(85)90043-4.
Bimolane has been shown to have good antitumor activity and on an equitoxic basis its activity is usually better than the chemically related razoxane. Resistance patterns of these two piperazinediones were similar. They exhibited cross-resistance to each other but little or no cross-resistance to most other clinically used drugs tested. Partial resistance was observed, however, between the piperazinediones and vincristine, daunorubicin and doxorubicin. The antitumor activities of three new analogs were compared with bimolane, ICRF-154 and razoxane against four rodent tumors. In general, bimolane was most effective.
丙脒腙已被证明具有良好的抗肿瘤活性，在同等毒性基础上，其活性通常优于化学相关的丙亚胺。这两种哌嗪二酮的耐药模式相似。它们彼此表现出交叉耐药性，但对大多数其他测试的临床常用药物几乎没有或没有交叉耐药性。然而，在哌嗪二酮与长春新碱、柔红霉素和阿霉素之间观察到部分耐药性。将三种新类似物的抗肿瘤活性与丙脒腙、ICRF-154和丙亚胺针对四种啮齿动物肿瘤进行了比较。一般来说，丙脒腙最有效。
