Department of Ophthalmology, The University of Auckland, Auckland, New Zealand.
Sci Rep. 2024 Apr 9;14(1):8264. doi: 10.1038/s41598-024-58670-y.
To assess the aetiologies, clinical characteristics, treatment regimens, and outcomes of acute chemical injuries treated at an emergency eye clinic. Retrospective, observational study of all cases of chemical eye injury that presented acutely to the Greenlane Clinical Centre in Auckland, New Zealand from 1 January 2012 through 31 December 2021. Patient demographics, activity at the time of injury, causative chemical, clinical characteristics of injury at presentation, severity (Dua) classification, admission and discharge best corrected visual acuity (BCVA), treatment regimen, time to epithelisation and number of follow-up appointments were recorded. In total, 1522 cases involving 1919 eyes were studied. The mean age was 40.6 ± 18.8 years and 65% were male. The majority of cases occurred at home (62%) and cleaning was the most common activity (38%). There were 1490 Grade I (98%), 22 Grade II (1.5%), 5 Grade III (0.3%), 1 Grade IV (0.07%), 0 Grade V, and 4 Grade VI (0.3%) cases. An epithelial defect was noted in 409 cases (26.9%), of which re-epithelialisation occurred within one week for 378 cases (92%) and within 30 days for 384 cases (94%). Moderate vision loss (BCVA ≤ 6/12) attributed to the injury occurred in 152 (10%), while severe vision loss (BCVA ≤ 6/60) occurred in 30 (2%). Lack of irrigation at the scene was associated with an increased risk of severe injury and longstanding visual impairment (p = 0.0001). Most acute chemical injuries are mild with good clinical outcomes. Although rare, severe injuries are associated with a lack of irrigation at the scene and worse visual outcomes.
评估在急诊眼科诊所治疗的急性化学性眼损伤的病因、临床特征、治疗方案和结局。对 2012 年 1 月 1 日至 2021 年 12 月 31 日期间在新西兰奥克兰格林兰临床中心急性就诊的所有化学性眼损伤病例进行回顾性、观察性研究。记录患者人口统计学特征、受伤时的活动、致伤化学物质、就诊时的损伤临床特征、严重程度(Dua)分类、入院和出院时的最佳矫正视力(BCVA)、治疗方案、上皮化时间和随访次数。共研究了 1522 例涉及 1919 只眼的病例。平均年龄为 40.6±18.8 岁,65%为男性。大多数病例发生在家庭(62%),清洁是最常见的活动(38%)。1490 例为 I 级(98%)、22 例为 II 级(1.5%)、5 例为 III 级(0.3%)、1 例为 IV 级(0.07%)、0 例为 V 级、4 例为 VI 级(0.3%)。409 例(26.9%)有上皮缺损,其中 378 例(92%)在一周内、384 例(94%)在 30 天内再上皮化。152 例(10%)因损伤导致中度视力丧失(BCVA≤6/12),30 例(2%)因损伤导致严重视力丧失(BCVA≤6/60)。现场缺乏冲洗与严重损伤和长期视力损害的风险增加相关(p=0.0001)。大多数急性化学性眼损伤为轻度,临床结局良好。尽管罕见,但严重损伤与现场缺乏冲洗和较差的视力结局相关。