At Emory University Hospital in Atlanta, Ga., James Beck practices in critical care, Jasleen K. Bolina is a clinical pharmacy specialist in critical care, and Lisa H. Boyd is lead advanced practice provider in critical care. The authors have disclosed no potential conflicts of interest, financial or otherwise.
JAAPA. 2024 May 1;37(5):22-27. doi: 10.1097/01.JAA.0000000000000001. Epub 2024 Apr 25.
Acute liver failure, commonly caused by acetaminophen overdose, is associated with numerous systemic complications including cerebral edema, hypotension, acute kidney injury, and infection. Management is primarily supportive, with an emphasis on excellent neurocritical care. Although some antidotes and targeted treatments exist, the only definitive treatment remains orthotopic liver transplant.
急性肝衰竭，通常由对乙酰氨基酚过量引起，与多种全身并发症相关，包括脑水肿、低血压、急性肾损伤和感染。治疗主要为支持性治疗，重点是进行神经重症监护。尽管存在一些解毒剂和靶向治疗方法，但唯一明确的治疗方法仍然是原位肝移植。
