Khan Mohammed Wajid Ali, Das Prajnyananda, Bhavani V, Thakkar Smit, Nagella Sai Prannoy, Dubey Alok
Consultant Anaesthetisiologist, Sai Vani Multispeciality Hospital, Hyderabad, Telangana, India.
Department of Anaesthesiology, Acharya Harihar Post Graduate Institute of Cancer, Cuttack, Odisha, India.
J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S305-S307. doi: 10.4103/jpbs.jpbs_502_23. Epub 2024 Feb 29.
Although sevoflurane and desflurane have nearly identical blood-gas solubilities, current research suggests that airway reflexes recover more quickly with desflurane than sevoflurane; however, cognitive function recovery varies substantially. The current study was piloted to appraise the lengths of time needed to recover from anesthesia following desflurane and sevoflurane anesthesia.
A prospective clinical trial was piloted among 70 adult non-obese subjects who underwent elective surgery and were classified I-II by the " (ASA)". Sevoflurane and desflurane were tested among the subjects who were equally distributed. These agents were used in accordance with a normal general anaesthesia procedure. After they were extubated, tests for regaining cognitive function and airway reflexes were carried out, and different time intervals were recorded. The observations were calculated and < 0.05 was used to conduct the statistical analysis.
The average amount of time that passed between the patient's first vocal response and their first successful completion of the swallowing test was analogous between the two groups (T2) with 5.25 ± 3.11 vs 5.01 ± 2.12 in sevoflurane and desflurane, respectively. There was no significant variance at T2. For all the other time intervals of T1, T3, and T4, there was evidence of the significant variance.( = 0.003; 0.0013; <0.001, respectively).
Desflurane causes patients to recover more quickly than sevoflurane does after laparoscopic cholecystectomy under controlled circumstances.
尽管七氟烷和地氟烷的血气溶解度几乎相同,但目前的研究表明,地氟烷使气道反射恢复得比七氟烷更快;然而,认知功能恢复情况差异很大。本研究旨在评估地氟烷和七氟烷麻醉后从麻醉中恢复所需的时间长度。
对70名接受择期手术且根据美国麻醉医师协会(ASA)分级为I-II级的成年非肥胖受试者进行了一项前瞻性临床试验。在地氟烷和七氟烷之间进行了测试,受试者被平均分配。这些药物按照正常的全身麻醉程序使用。拔管后,进行了认知功能和气道反射恢复测试,并记录了不同的时间间隔。计算观察结果并使用<0.05进行统计分析。
两组患者从首次发声反应到首次成功完成吞咽测试之间的平均时间类似(T2),七氟烷组为5.25±3.11,地氟烷组为5.01±2.12。T2时无显著差异。对于T1、T3和T4的所有其他时间间隔,均有显著差异的证据(分别为=0.003;0.0013;<0.001)。
在可控情况下,腹腔镜胆囊切除术后,地氟烷使患者比七氟烷恢复得更快。