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泰国特定病因住院与高温和低温的关联:一项全国性时间序列研究。

Association of cause-specific hospital admissions with high and low temperatures in Thailand: a nationwide time series study.

作者信息

Wen Bo, Kliengchuay Wissanupong, Suwanmanee San, Aung Htoo Wai, Sahanavin Narut, Siriratruengsuk Weerayut, Kawichai Sawaeng, Tawatsupa Benjawan, Xu Rongbin, Li Shanshan, Guo Yuming, Tantrakarnapa Kraichat

机构信息

Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

Lancet Reg Health West Pac. 2024 Apr 4;46:101058. doi: 10.1016/j.lanwpc.2024.101058. eCollection 2024 May.

Abstract

BACKGROUND

Non-optimum temperatures are associated with a considerable mortality burden. However, evidence of temperature with all-cause and cause-specific hospital admissions in tropical countries like Thailand is still limited.

METHODS

Daily all-cause and cause-specific hospital admissions for outpatient and inpatient visits were collected from 77 provinces in Thailand from January 2013 to August 2019. A two-stage time-series approach was applied to assess the association between non-optimum temperatures and hospital admission. We first fitted the province-specific temperature-morbidity association and then obtained the national association in the second stage using a random-effects meta-analysis regression. The attributable fraction (AF) of hospital admissions with 95% empirical confidence interval (eCI) was calculated.

FINDINGS

A total of 878,513,460 all-cause outpatient admissions and 32,616,600 all-cause inpatient admissions were included in this study. We observed a J-shaped relationship with the risk of hospital admissions increasing for both cold and hot temperatures. The overall AFs of all-cause hospital admissions due to non-optimum temperatures were 7.57% (95% eCI: 6.47%, 8.39%) for outpatient visits and 6.17% (95% eCI: 4.88%, 7.20%) for inpatient visits. Hot temperatures were responsible for most of the AFs of hospital admissions, with 6.71% (95% eCI: 5.80%, 7.41%) for outpatient visits and 4.50% (95% eCI: 3.62%, 5.19%) for inpatient visits. The burden of hospital admissions was greater in females and in children and adolescents (0-19 years). The fractions of hospital admissions attributable to non-optimum temperatures exhibited variation among disease categories and geographical areas.

INTERPRETATION

The results indicate that low and high temperature has a significant impact on hospital admissions, especially among the females, and children and adolescents (0-19 years). The current investigation could provide evidence for policymakers to develop adaptation strategies and mitigate the adverse effects of climate change on public health in Thailand and other tropical countries.

FUNDING

National Research Council of Thailand (NRCT): E-Asia Joint Research Program: Climate change impact on natural and human systems (N33A650979).

摘要

背景

非适宜温度与相当大的死亡负担相关。然而,在泰国等热带国家,关于温度与全因及特定病因住院情况的证据仍然有限。

方法

收集了2013年1月至2019年8月泰国77个省份每日门诊和住院的全因及特定病因住院数据。采用两阶段时间序列方法评估非适宜温度与住院之间的关联。我们首先拟合特定省份的温度 - 发病率关联,然后在第二阶段使用随机效应荟萃分析回归得出全国性关联。计算了住院的归因分数(AF)及其95%经验置信区间(eCI)。

结果

本研究共纳入878,513,460例全因门诊住院病例和32,616,600例全因住院病例。我们观察到温度与住院风险呈J形关系,低温和高温时住院风险均增加。非适宜温度导致的全因住院病例的总体归因分数,门诊为7.57%(95% eCI:6.47%,8.39%),住院为6.17%(95% eCI:4.88%,7.20%)。高温导致的住院归因分数占大部分,门诊为6.71%(95% eCI:5.80%,7.41%),住院为4.50%(95% eCI:3.62%,5.19%)。女性以及儿童和青少年(0 - 19岁)的住院负担更大。非适宜温度导致的住院病例比例在疾病类别和地理区域之间存在差异。

解读

结果表明,低温和高温对住院有显著影响,尤其是对女性以及儿童和青少年(0 - 19岁)。当前的调查可为政策制定者制定适应策略和减轻气候变化对泰国及其他热带国家公众健康的不利影响提供证据。

资金来源

泰国国家研究委员会(NRCT):东亚联合研究计划:气候变化对自然和人类系统的影响(N33A650979)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa89/11000193/0268b1571ece/gr1.jpg

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