Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, PR China.
College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, PR China.
Anim Biotechnol. 2024 Nov;35(1):2337751. doi: 10.1080/10495398.2024.2337751. Epub 2024 Apr 10.
The economic efficiency of sheep breeding, aiming to enhance productivity, is a focal point for improvement of sheep breeding. Recent studies highlight the involvement of the 8 ( gene in female reproduction. Our group's recent genome-wide association study (GWAS) emphasizes the potential impact of the gene on prolificacy traits in Australian White sheep (AUW). Herein, the purpose of this study was to assess the correlation of the gene with litter size in AUW sheep breed. This work encompassed 659 AUW sheep, subject to genotyping through PCR-based genotyping technology. Furthermore, the results of PCR-based genotyping showed significant associations between the P1-del-32bp bp InDel and the fourth and fifth parities litter size in AUW sheep; the litter size of those with genotype ID were superior compared to those with DD and II genotypes. Thus, these results indicate that the P1-del-32bp InDel within the gene can be useful in marker-assisted selection (MAS) in sheep.
绵羊养殖的经济效益旨在提高生产力，是提高绵羊养殖水平的重点。最近的研究强调了 8 号基因在雌性生殖中的作用。我们小组最近的全基因组关联研究（GWAS）强调了 基因对澳大利亚白绵羊（AUW）多产性状的潜在影响。在此，本研究旨在评估 基因与 AUW 绵羊产羔数的相关性。本研究共涉及 659 只 AUW 绵羊，通过基于 PCR 的基因分型技术进行基因分型。此外，基于 PCR 的基因分型结果显示，P1-del-32bp bp 插入缺失与 AUW 绵羊第四和第五胎产羔数之间存在显著关联；基因型为 ID 的绵羊的产羔数优于基因型为 DD 和 II 的绵羊。因此，这些结果表明，基因内的 P1-del-32bp 插入缺失可以在绵羊的标记辅助选择（MAS）中发挥作用。
