Processed electroencephalography-guided general anesthesia and norepinephrine requirements: A randomized trial in patients having vascular surgery.

STUDY OBJECTIVE

Processed electroencephalography (pEEG) may help clinicians optimize depth of general anesthesia. Avoiding excessive depth of anesthesia may reduce intraoperative hypotension and the need for vasopressors. We tested the hypothesis that pEEG-guided - compared to non-pEEG-guided - general anesthesia reduces the amount of norepinephrine needed to keep intraoperative mean arterial pressure above 65 mmHg in patients having vascular surgery.

DESIGN

Randomized controlled clinical trial.

SETTING

University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

PATIENTS

110 patients having vascular surgery.

INTERVENTIONS

pEEG-guided general anesthesia.

MEASUREMENTS

Our primary endpoint was the average norepinephrine infusion rate from the beginning of induction of anesthesia until the end of surgery.

MAIN RESULT

96 patients were analyzed. The mean ± standard deviation average norepinephrine infusion rate was 0.08 ± 0.04 μg kg min in patients assigned to pEEG-guided and 0.12 ± 0.09 μg kg min in patients assigned to non-pEEG-guided general anesthesia (mean difference 0.04 μg kg min, 95% confidence interval 0.01 to 0.07 μg kg min, p = 0.004). Patients assigned to pEEG-guided versus non-pEEG-guided general anesthesia, had a median time-weighted minimum alveolar concentration of 0.7 (0.6, 0.8) versus 0.8 (0.7, 0.8) (p = 0.006) and a median percentage of time Patient State Index was <25 of 12 (1, 41) % versus 23 (3, 49) % (p = 0.279).

CONCLUSION

pEEG-guided - compared to non-pEEG-guided - general anesthesia reduced the amount of norepinephrine needed to keep mean arterial pressure above 65 mmHg by about a third in patients having vascular surgery. Whether reduced intraoperative norepinephrine requirements resulting from pEEG-guided general anesthesia translate into improved patient-centered outcomes remains to be determined in larger trials.