Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA.
Immunity. 2024 Apr 9;57(4):832-834. doi: 10.1016/j.immuni.2024.03.009.
IL-23 activates pathogenic Th17 cells to drive inflammatory disease at barrier surfaces. Kim et al. now identify oral epithelial cells as the critical producers of IL-23 in human and mouse periodontitis, linking microbial dysbiosis to non-hematopoietic regulation of IL-17-associated inflammation.
IL-23 激活致病性 Th17 细胞，在屏障表面引发炎症性疾病。Kim 等人现在确定口腔上皮细胞是人类和小鼠牙周炎中 IL-23 的关键产生细胞，将微生物失调与非造血细胞对 IL-17 相关炎症的调控联系起来。
