Colly L P, Willemze R, Honders W, vd Hoorn F, Edelbroek P M
Semin Oncol. 1985 Jun;12(2 Suppl 3):49-54.
From the current studies it can be concluded that comparing the ara-C catabolism to ara-U in leukemic rats and leukemic patients, this process is about 100 times more pronounced in human leukemic cells. The low deaminase activity in leukemic rats probably explains the slow plasma ara-C disappearance curve in the BNML. No cytotoxic effect of ara-U with respect to LCFU-S reduction could be observed, nor did ara-U enhance the cytotoxic effect ara-C in the BNML. These studies have increased the understanding of the relation between ara-C, ara-U plasma levels and deaminase activity.
从目前的研究可以得出结论，在白血病大鼠和白血病患者中比较阿糖胞苷（ara-C）与阿糖尿苷（ara-U）的分解代谢，这一过程在人类白血病细胞中明显约为100倍。白血病大鼠中脱氨酶活性较低可能解释了BNML中血浆阿糖胞苷消失曲线缓慢的原因。未观察到阿糖尿苷对集落形成单位脾细胞（LCFU-S）减少有细胞毒性作用，在BNML中阿糖尿苷也未增强阿糖胞苷的细胞毒性作用。这些研究增进了对阿糖胞苷、阿糖尿苷血浆水平与脱氨酶活性之间关系的理解。
