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用于治疗肘感染的抗生素骨水泥间隔物的并发症。

Complications of antibiotic cement spacers used for elbow infections.

机构信息

Department of Orthopedics, Mayo Clinic, Rochester, MN, USA; Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Department of Orthopedics, Mayo Clinic, Rochester, MN, USA; Department of Orthopedics and Traumatology, Fundación Santa Fe de Bogotá, Bogotá, Colombia.

出版信息

J Shoulder Elbow Surg. 2024 Jul;33(7):1624-1632. doi: 10.1016/j.jse.2024.02.033. Epub 2024 Apr 9.

DOI:10.1016/j.jse.2024.02.033
PMID:38599456
Abstract

BACKGROUND

Antibiotic cement spacers have been widely used in the treatment of joint infections. There are no commercially available antibiotic spacers for the elbow. Instead, they are typically fashioned by the surgeon at the time of surgery using cement alone or a combination of cement with sutures, Steinmann pins, external fixator components, or elbow arthroplasty components. There is no consensus regarding the ideal elbow antibiotic spacer and no previous studies have examined the complications associated with these handmade implants in relation to their unique structural design.

METHODS

We retrospectively reviewed 55 patients who had 78 static antibiotic cement spacers implanted between January 1998 and February 2021 as part of a 2-stage treatment plan for infection of an elbow arthroplasty, other elbow surgery, or primary elbow infection. Several antibiotic spacer structures were used during the study period. For analysis purposes, the spacers were classified into linked and unlinked spacers based on whether there was a linking mechanism between the humerus and the ulna. Complications related to these spacers that occurred either during the implantation, between implantation and removal, or during removal were recorded and analyzed from chart review and follow-up x rays. Reoperations due to spacer-related complications were also recorded.

RESULTS

Among the 55 patients (78 spacers), there were 23 complications, including 17 minor and 6 major complications. The most common complication of unlinked spacers (intramedullary [IM] dowels, beads and cap spacer) was spacer displacement. Other complications included IM dowel fracture and difficulty locating beads during spacer removal. The major complications of linked cement spacers included two periprosthetic humerus fractures after internal external fixator cement spacers and re-operation due to breakage and displacement of one bushing cement spacer. The major complications of unlinked cement spacers included two reoperations due to IM dowel displacement and one reoperation due to displacement of beads. Among patients who had removal of all components and those with native joints, there was no statistically significant difference between internal external fixator cement spacers and unlinked cement spacers in minor complication rates (30% vs. 16%, P = .16), major complication rates (7% vs. 8%, P = .85) and reoperation rates (0% vs. 8%, P = .12).

CONCLUSIONS

Static handmade antibiotic elbow spacers have unique complications related to their structural designs. The most common complication of linked and nonlinked cement spacers were failure of the linking mechanism and displacement, respectively. Surgeons should keep in mind the possible complications of different structures of cement spacers when choosing 1 antibiotic spacer structure over another.

摘要

背景

抗生素骨水泥间隔物在治疗关节感染方面得到了广泛应用。目前还没有市售的用于肘关节感染的抗生素间隔物。相反,通常由外科医生在手术时使用单独的骨水泥或骨水泥与缝线、斯氏针、外固定器部件或肘部关节置换部件的组合来制作。对于理想的肘部抗生素间隔物,目前尚无共识,也没有研究探讨与这些手工植入物相关的并发症与它们独特的结构设计之间的关系。

方法

我们回顾性分析了 1998 年 1 月至 2021 年 2 月期间,作为 2 期治疗方案的一部分,55 例患者(78 个静态抗生素骨水泥间隔物)接受了关节成形术、其他肘部手术或原发性肘部感染的感染治疗。在研究期间使用了几种抗生素间隔物结构。为了分析目的,根据肱骨和尺骨之间是否存在连接机制,将间隔物分为连接和非连接间隔物。从病历回顾和随访 X 光片中记录并分析了植入过程中、植入和取出之间或取出过程中与这些间隔物相关的并发症。还记录了因间隔物相关并发症而进行的再次手术。

结果

在 55 例患者(78 个间隔物)中,有 23 例并发症,包括 17 例轻微并发症和 6 例严重并发症。非连接间隔物(髓内 [IM] 栓子、珠和帽状间隔物)最常见的并发症是间隔物移位。其他并发症包括 IM 栓子骨折和在间隔物取出过程中难以找到珠粒。连接的水泥间隔物的主要并发症包括内固定器水泥间隔物后发生的 2 例肱骨干周围骨折和 1 例因衬套水泥间隔物断裂和移位而再次手术。非连接水泥间隔物的主要并发症包括 2 例因 IM 栓子移位和 1 例因珠粒移位而进行的 2 次手术。在所有部件均已取出的患者和保留自然关节的患者中,内固定器水泥间隔物和非连接水泥间隔物在轻微并发症发生率(30%比 16%,P=0.16)、严重并发症发生率(7%比 8%,P=0.85)和再次手术率(0%比 8%,P=0.12)方面无统计学差异。

结论

静态手工制作的抗生素肘间隔物具有与结构设计相关的独特并发症。连接和非连接水泥间隔物的最常见并发症分别为连接机制失效和移位。外科医生在选择 1 种抗生素间隔物结构时,应考虑到不同结构的水泥间隔物可能存在的并发症。

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