Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Ageing Res Rev. 2024 Jun;97:102297. doi: 10.1016/j.arr.2024.102297. Epub 2024 Apr 9.
Hepatocellular carcinoma is a common and highly lethal tumour. The tumour microenvironment (TME) plays an important role in the progression and metastasis of hepatocellular carcinoma (HCC). A cell death mechanism, termed NETosis, has been found to play an important role in the TME of HCC.
This review article focuses on the role of NETosis in the TME of HCC, a novel form of cell death in which neutrophils capture and kill microorganisms by releasing a type of DNA meshwork fibres called "NETs". This process is associated with neutrophil activation, local inflammation and cytokines. The study suggests that NETs play a multifaceted role in the development and metastasis of HCC. The article also discusses the role of NETs in tumour proliferation and metastasis, epithelial-mesenchymal transition (EMT), and surgical stress. In addition, the article discusses the interaction of NETosis with other immune cells in the TME and related therapeutic strategies. A deeper understanding of NETosis can help us better understand the complexity of the immune system and provide a new therapeutic basis for the treatment and prevention of HCC.
In conclusion, NETosis is important in the TME of liver. NETs have been shown to contribute to the progression and metastasis of liver cancer. The interaction between NETosis and immune cells in the TME, as well as related therapies, are important areas of research.
肝细胞癌是一种常见且高度致命的肿瘤。肿瘤微环境（TME）在肝细胞癌（HCC）的进展和转移中起着重要作用。一种称为 NETosis 的细胞死亡机制已被发现在 HCC 的 TME 中发挥重要作用。
本文重点介绍 NETosis 在 HCC 的 TME 中的作用，NETosis 是一种新型的细胞死亡形式，其中中性粒细胞通过释放一种称为“NETs”的 DNA 网状纤维来捕获和杀死微生物。这一过程与中性粒细胞的激活、局部炎症和细胞因子有关。研究表明，NETs 在 HCC 的发生和转移中起着多方面的作用。本文还讨论了 NETs 在肿瘤增殖和转移、上皮-间充质转化（EMT）以及手术应激中的作用。此外，文章还讨论了 NETosis 与 TME 中其他免疫细胞的相互作用以及相关的治疗策略。对 NETosis 的深入了解可以帮助我们更好地理解免疫系统的复杂性，并为 HCC 的治疗和预防提供新的治疗基础。
总之，NETosis 在肝脏的 TME 中很重要。NETs 已被证明有助于肝癌的进展和转移。NETosis 与 TME 中免疫细胞的相互作用以及相关的治疗方法是重要的研究领域。
