Clinical Laboratory, The Disease Control and Prevention Laboratory Center of Tongnan District, Chongqing, China.
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Biosci Biotechnol Biochem. 2024 Jun 21;88(7):727-732. doi: 10.1093/bbb/zbae045.
The chemical investigation of the roots of Lindera glauca guided the isolation and identification of 3 new sesquiterpenoids, namely glaucatotones J-L (1-3), and one known congener, (1β,5β)-1-hydroxyguaia-4(15),11(13)-dieno-12,5-lactone (4). The structures of new compounds were established based on comprehensive spectrographic methods, mainly including 1D & 2D NMR and HRESIMS analyses, and the absolute configurations were further confirmed by the comparison of experimental and calculated electronic circular dichroism. The cytotoxicity activities of isolates were evaluated, and the results showed that they have moderate cytotoxic activities.
对黄瑞木根的化学成分研究指导了 3 种新的倍半萜的分离和鉴定，分别为黄瑞酮 J-L（1-3），以及一种已知的同系物，（1β,5β）-1-羟基-1,4-二烯-12,5-内酯（4）。新化合物的结构是基于综合光谱方法建立的，主要包括 1D 和 2D NMR 以及 HRESIMS 分析，并通过实验和计算电子圆二色谱的比较进一步确定了它们的绝对构型。对分离得到的化合物进行了细胞毒性活性评价，结果表明它们具有中等的细胞毒性活性。
