Zhonghua Jie He He Hu Xi Za Zhi. 2024 Apr 12;47(4):301-312. doi: 10.3760/cma.j.cn112147-20231010-00215.
The incidence and mortality of lung cancer in China are the highest of all malignant tumors, seriously endangering people's lives and health. Refractory lung cancer is lung cancer that is unresponsive to standard treatment and is difficult to treat, or lung cancer for which a standard treatment has not yet been defined. However, there is still a lack of clear definition and consensus on the treatment of refractory lung cancer. In order to provide guidance for the clinically effective and safe treatment of refractory lung cancer, experts from Chinese Thoracic Society Lung Cancer Study Group have formulated this consensus, on the basis of the actual situation in the field of diagnosis and treatment in our country, with reference to the latest research data, relevant guidelines at home and abroad and experts' clinical practice experience. The consensus makes recommendations on the application of four aspects: refractory small cell lung cancer (SCLC), refractory driver gene-positive non-small cell lung cancer (NSCLC), refractory driver gene-negative NSCLC, and new technological solutions for precision diagnosis and treatment. It also provides references for Chinese clinicians on the use of drugs for refractory lung cancer.
中国肺癌的发病率和死亡率在所有恶性肿瘤中位居首位,严重危及人们的生命健康。难治性肺癌是指对标准治疗无反应且难以治疗的肺癌,或尚未明确标准治疗方案的肺癌。然而,对于难治性肺癌的治疗仍缺乏明确的定义和共识。为了为难治性肺癌的临床有效和安全治疗提供指导,中国临床肿瘤学会(CSCO)肺癌研究专家组的专家们,根据我国诊断和治疗领域的实际情况,参考最新研究数据、国内外相关指南以及专家的临床实践经验,制定了本共识。该共识对难治性小细胞肺癌(SCLC)、难治性驱动基因阳性非小细胞肺癌(NSCLC)、难治性驱动基因阴性NSCLC以及精准诊断和治疗的新技术解决方案这四个方面的应用提出了建议。它也为中国临床医生使用难治性肺癌药物提供了参考。