Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.
Trends Endocrinol Metab. 2024 Jun;35(6):456-458. doi: 10.1016/j.tem.2024.04.001. Epub 2024 Apr 9.
Obesity is associated with dysfunctions in hypothalamic neurons that regulate metabolism, including agouti-related protein (AgRP)-expressing neurons. In a recent article, Zhang et al. demonstrated that either diet- or genetically induced obesity promoted iron accumulation specifically in AgRP neurons. Preventing iron overload in AgRP neurons mitigated diet-induced obesity and related comorbidities in male mice.
肥胖与调节代谢的下丘脑神经元功能障碍有关，包括表达 AgRP（刺鼠相关蛋白）的神经元。在最近的一篇文章中，Zhang 等人表明，饮食或遗传诱导的肥胖会特异性促进 AgRP 神经元中铁的积累。预防 AgRP 神经元中铁过载可减轻雄性小鼠饮食诱导的肥胖及其相关合并症。
