Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Clin Radiol. 2024 Jul;79(7):544-552. doi: 10.1016/j.crad.2024.03.005. Epub 2024 Mar 19.
Left atrial (LA) dysfunction is involved in idiopathic inflammatory myopathy (IIM). Multiparametric cardiovascular magnetic resonance (CMR) strain imaging is a feasible and reproducible tool for examining global and regional LA functions, as well as left ventricular (LV) function in IIM patients.
The aim of this study was to evaluate the feasibility and reproducibility of LA strain occurrence and strain rate for LA function assessment using CMR in IIM cases.
A total of 36 IIM and 42 healthy control cases were included. Baseline ventricular function was comparatively assessed in both groups. LA strain occurrence and strain rate were examined by cine cardiac magnetic resonance imaging [MRI] utilizing an in-house semiautomated technique. LA global function indexes were quantitated, including reservoir, conduit, and booster-pump functions.
A total of 78 participants were enrolled in this study. There was no significant difference in left/right ventricular routine functions between IIM patients and control individuals (p>0.05); the same results (p>0.05) was also observed between patients with high hs-cTnI and normal. However, LV mass index had significant difference (p1=0.003, p2<0.01). Compared with IIM patients and control individuals, only total strain (εs) (p4=0.046) and passive strain (εe) (p4=0.002) showed significant difference, and in cases with high hs-cTnI and normal hs-cTnI, there are differences for εs (p3=0.012) and εe (p4=0.047). The strongest association was found between εe and LV ejection fraction (LVEF) (r=0.581, p<0.01).
IIM cases have altered LA reservoir and conduit functions, and LA strain could reflect LA function.
左心房（LA）功能障碍与特发性炎症性肌病（IIM）有关。多参数心血管磁共振（CMR）应变成像是一种可行且可重复的工具，可用于检查 IIM 患者的整体和局部 LA 功能以及左心室（LV）功能。
本研究旨在评估 CMR 应变发生和应变率用于评估 IIM 病例 LA 功能的可行性和可重复性。
共纳入 36 例 IIM 和 42 例健康对照组。比较两组的基础心室功能。使用心脏电影磁共振成像（MRI）利用内部半自动技术检查 LA 应变发生和应变率。定量评估 LA 整体功能指标，包括储器、导管和助推泵功能。
本研究共纳入 78 名参与者。IIM 患者与对照组个体之间的左/右心室常规功能无显著差异（p>0.05）；高 hs-cTnI 和正常 hs-cTnI 的患者之间也观察到相同的结果（p>0.05）。然而，LV 质量指数有显著差异（p1=0.003，p2<0.01）。与 IIM 患者和对照组个体相比，只有总应变（εs）（p4=0.046）和被动应变（εe）（p4=0.002）有显著差异，在高 hs-cTnI 和正常 hs-cTnI 的情况下，εs（p3=0.012）和 εe（p4=0.047）也有差异。εe 与 LVEF（r=0.581，p<0.01）之间存在最强关联。
IIM 病例有改变的 LA 储器和导管功能，LA 应变可以反映 LA 功能。
