Munster Drayton W, Lewandowski Beth E, Nelson Emily S, Prabhu R K, Myers Jerry G
NASA Glenn Research Center, 21000 Brookpark Road, Cleveland, OH, 44135, USA.
Universities Space Research Association, 21000 Brookpark Road, Cleveland, OH, 44135, USA.
NPJ Microgravity. 2024 Apr 10;10(1):46. doi: 10.1038/s41526-024-00385-5.
A potential contribution to the progression of Spaceflight Associated Neuro-ocular Syndrome is the thoracic-to-spinal dural sac transmural pressure relationship. In this study, we utilize a lumped-parameter computational model of human cerebrospinal fluid (CSF) systems to investigate mechanisms of CSF redistribution. We present two analyses to illustrate potential mechanisms for CSF pressure alterations similar to those observed in microgravity conditions. Our numerical evidence suggests that the compliant relationship between thoracic and CSF compartments is insufficient to solely explain the observed decrease in CSF pressure with respect to the supine position. Our analyses suggest that the interaction between thoracic pressure and the cardiovascular system, particularly the central veins, has greater influence on CSF pressure. These results indicate that future studies should focus on the holistic system, with the impact of cardiovascular changes to the CSF pressure emphasized over the sequestration of fluid in the spine.
胸段至脊髓硬膜囊跨壁压力关系可能对航天相关神经-眼综合征的进展有影响。在本研究中，我们利用人体脑脊液（CSF）系统的集总参数计算模型来研究脑脊液再分布的机制。我们进行了两项分析，以说明脑脊液压力改变的潜在机制，这些改变类似于在微重力条件下观察到的情况。我们的数值证据表明，胸段与脑脊液腔室之间的顺应性关系不足以单独解释观察到的脑脊液压力相对于仰卧位的降低。我们的分析表明，胸段压力与心血管系统，特别是中心静脉之间的相互作用对脑脊液压力有更大影响。这些结果表明，未来的研究应关注整体系统，强调心血管变化对脑脊液压力的影响，而不是脊髓中液体的潴留。
