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重复采样在原发性醛固酮增多症肾上腺静脉采样双侧醛固酮抑制中的效用

Utility of Repeat Sampling in Bilateral Aldosterone Suppression During Adrenal Vein Sampling for Primary Aldosteronism.

作者信息

Halim Bella, Yong Eric X Z, Egan Matthew, MacIsaac Richard J, O'Neal David, Sachithanandan Nirupa

机构信息

Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne, Fitzroy, Victoria 3065, Australia.

Department of Medicine, The University of Melbourne, Fitzroy, Victoria 3065, Australia.

出版信息

JCEM Case Rep. 2024 Apr 10;2(4):luae051. doi: 10.1210/jcemcr/luae051. eCollection 2024 Apr.

DOI:10.1210/jcemcr/luae051
PMID:38601064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11005832/
Abstract

Primary aldosteronism (PA) is the most common form of secondary hypertension. Accurate subtyping of PA is essential to identify unilateral disease, as adrenalectomy improves outcomes. Subtyping PA requires adrenal vein sampling (AVS), which is technically challenging and results from AVS may not always be conclusive. We present a case of a 37-year-old man with PA whose AVS studies were inconclusive due to apparent bilateral aldosterone suppression (ABAS). As a result, our patient was misdiagnosed as having bilateral PA and medically managed until a repeat AVS showed lateralization to the right adrenal gland. ABAS is an underrecognized phenomenon that may confound the subtyping of PA. We recommend repeating AVS in such cases and discuss strategies to minimize ABAS.

摘要

原发性醛固酮增多症(PA)是继发性高血压最常见的形式。准确对PA进行亚型分类对于识别单侧疾病至关重要,因为肾上腺切除术可改善治疗效果。对PA进行亚型分类需要肾上腺静脉采血(AVS),这在技术上具有挑战性,且AVS的结果可能并不总是具有决定性意义。我们报告一例37岁患有PA的男性病例,其AVS检查结果不明确,原因是出现了明显的双侧醛固酮抑制(ABAS)。结果,我们的患者被误诊为双侧PA并接受药物治疗,直到再次进行AVS检查显示右侧肾上腺有侧化表现。ABAS是一种未被充分认识的现象,可能会混淆PA的亚型分类。我们建议在这种情况下重复进行AVS检查,并讨论将ABAS降至最低的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/a26c2212ea1b/luae051f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/7c39b14c4932/luae051f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/9009d850c2b5/luae051f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/03200c06161c/luae051f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/69840698f5a3/luae051f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/91e00fb43571/luae051f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/a26c2212ea1b/luae051f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/7c39b14c4932/luae051f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/9009d850c2b5/luae051f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/03200c06161c/luae051f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/69840698f5a3/luae051f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/91e00fb43571/luae051f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f6a/11005832/a26c2212ea1b/luae051f6.jpg

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引用本文的文献

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本文引用的文献

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Unilaterally Successful Adrenal Vein Sampling: Use or Repeat?单侧成功的肾上腺静脉采血:使用还是重复?
Hypertension. 2023 Oct;80(10):2014-2016. doi: 10.1161/HYPERTENSIONAHA.123.21563. Epub 2023 Sep 20.
2
Duplicated adrenal veins in primary aldosteronism misdiagnosed with ectopic aldosteronoma due to apparent bilateral aldosterone suppression.原发性醛固酮增多症中因双侧醛固酮明显抑制而误诊为异位醛固酮瘤的重复肾上腺静脉。
Blood Press. 2023 Dec;32(1):2209664. doi: 10.1080/08037051.2023.2209664.
3
Diagnosis and treatment of primary aldosteronism.
原发性醛固酮增多症的诊断与治疗。
Lancet Diabetes Endocrinol. 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2.
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Improvement in quality of life and psychological symptoms after treatment for primary aldosteronism: Asian Cohort Study.原发性醛固酮增多症治疗后生活质量和心理症状的改善:亚洲队列研究
Endocr Connect. 2021 Jul 26;10(8):834-844. doi: 10.1530/EC-21-0125.
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Composite Cardiovascular Outcomes in Patients With Primary Aldosteronism Undergoing Medical Versus Surgical Treatment: A Meta-Analysis.原发性醛固酮增多症患者接受药物与手术治疗的复合心血管结局:一项荟萃分析。
Front Endocrinol (Lausanne). 2021 May 17;12:644260. doi: 10.3389/fendo.2021.644260. eCollection 2021.
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Adrenal vein sampling: technique and protocol, a systematic review.肾上腺静脉采血:技术与方案,一项系统评价
CVIR Endovasc. 2021 Apr 1;4(1):38. doi: 10.1186/s42155-021-00220-y.
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"Double-Down" Adrenal Vein Sampling Results in Patients with Apparent Bilateral Aldosterone Suppression: Utility of Repeat Sampling including Super-Selective Sampling.在双侧醛固酮抑制表现明显的患者中,“加倍”肾上腺静脉采样结果:包括超选择性采样在内的重复采样的效用。
J Vasc Interv Radiol. 2021 May;32(5):656-665. doi: 10.1016/j.jvir.2020.12.029. Epub 2021 Mar 27.
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