Gómez-Gutiérrez Maria Alejandra, Huertas-Cañas Juan Miguel, Bedoya-Ossa Andrés
Faculty of Medicine, Pontificia Universidad Javeriana, Bogotá, 110231, Colombia.
Department of Physiological Sciences, Faculty of Medicine, Pontificia Universidad Javeriana, Bogotá, 110231, Colombia.
JCEM Case Rep. 2024 Apr 10;2(4):luae048. doi: 10.1210/jcemcr/luae048. eCollection 2024 Apr.
Cushing syndrome (CS) is a rare endocrinological disorder resulting from chronic exposure to excessive cortisol. The term is used specifically when this is caused by excessive secretion of adrenocorticotropic hormone (ACTH) by a pituitary tumor, usually an adenoma. This disease is associated with a poor prognosis, and if left untreated, it has an estimated 5-year survival rate of 50%. We present the case of a 66-year-old female patient who received a referral to endocrinology for an evaluation of obesity due to right knee arthropathy. Taking into consideration her age, she was screened for osteoporosis, with results that showed diminished bone density. Considering this, combined with other clinical features of the patient, suspicion turned toward hypercortisolism. Laboratory findings suggested that the CS was ACTH-dependent and originated in the pituitary gland. After a second look at the magnetic resonance imaging results, a 4-mm lesion was identified on the pituitary gland, prompting a transsphenoidal resection of the pituitary adenoma.
库欣综合征（CS）是一种罕见的内分泌紊乱疾病，由长期暴露于过量皮质醇引起。当这种情况由垂体肿瘤（通常是腺瘤）过度分泌促肾上腺皮质激素（ACTH）所致时，就专门使用该术语。这种疾病预后较差，如果不治疗，估计5年生存率为50%。我们报告一例66岁女性患者，因右膝关节病导致肥胖而被转诊至内分泌科进行评估。考虑到她的年龄，对其进行了骨质疏松筛查，结果显示骨密度降低。鉴于此，结合患者的其他临床特征，怀疑转向皮质醇增多症。实验室检查结果表明，该库欣综合征依赖促肾上腺皮质激素，起源于垂体。再次查看磁共振成像结果后，在垂体上发现一个4毫米的病变，促使对垂体腺瘤进行经蝶窦切除术。
