Xueyan Hou, Qi Ai, Chunming Song, Yu Zhi, Wencai Weng
Department of Radiology, Xinhua Hospital Affiliated to Dalian University, Dalian, Liaoning, China.
Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Front Neurol. 2024 Mar 27;15:1357274. doi: 10.3389/fneur.2024.1357274. eCollection 2024.
To explore white matter network topological properties changes in middle-aged and elderly patients with functional constipation (Functional Constipation, FC) by diffusion tensor imaging (DTI), and to evaluate the correlation between the abnormal changes and clinical data.
29 FC patients and 31 age- and sex-matched healthy controls (HC) were recruited. Magnetic resonance imaging and clinical data were collected. The white matter network changes in FC patients were analyzed using deterministic fiber tracking methods, graph theory algorithms, and partial correlation analysis with clinical data.
The nodal clustering coefficient and nodal local efficiency of FC patients in the right orbital inferior frontal gyrus, right medial superior frontal gyrus, right rectus muscle, right hippocampus, left paracentral lobule and left temporal pole, and the nodal clustering coefficient in right orbital superior frontal gyrus, left cuneus lobe and right superior occipital gyrus, the nodal local efficiency in the right medial and paracingulate gyrus, right precuneus and right dorsolateral superior frontal gyrus of FC patients are lower than that of HC. The nodal local efficiency and clustering coefficient of FC patients in left hippocampus, left amygdala, right parietal inferior limbic angular gyrus and right angular gyrus, the nodal local efficiency in the right fusiform gyrus, left supplementary motor cortex and the nodal efficiency in the left lateral temporal gyrus and right orbital middle frontal gyrus (ORBmid.R) of FC patients are higher than that of HC. The nodal efficiency of ORBmid.R in FC was positively correlated with the Patient Assessment of Constipation quality of life questionnaire (PAC-QoL).
Middle-aged and elderly FC patients have differences in the nodal level properties in the limbic system, supplementary motor cortex, and default mode network brain regions, and the nodal efficiency of ORBmid.R was positively correlated with the PAC-QoL score, revealing that FC may be related to the abnormal processing of visceral sensorimotor in ORBmid.R and providing potential imaging diagnostic markers and therapeutic targets for middle-aged and elderly FC patients.
通过弥散张量成像（DTI）探讨中老年功能性便秘（FC）患者白质网络拓扑属性的变化，并评估这些异常变化与临床数据之间的相关性。
招募29例FC患者和31例年龄及性别匹配的健康对照（HC）。收集磁共振成像和临床数据。采用确定性纤维追踪方法、图论算法以及与临床数据的偏相关分析，分析FC患者白质网络的变化。
FC患者右侧眶额下回、右侧额上回内侧、右侧直肌、右侧海马、左侧中央旁小叶和左侧颞极的节点聚类系数和节点局部效率，以及右侧眶额上回、左侧楔叶和右侧枕上回的节点聚类系数，右侧额内侧回和扣带旁回、右侧楔前叶和右侧额上回背外侧的节点局部效率均低于HC。FC患者左侧海马、左侧杏仁核、右侧顶叶下边缘角回和右侧角回的节点局部效率和聚类系数，右侧梭状回、左侧辅助运动皮层的节点局部效率以及左侧颞叶外侧回和右侧眶额中回（ORBmid.R）的节点效率均高于HC。FC患者中ORBmid.R的节点效率与便秘患者生活质量问卷（PAC-QoL）呈正相关。
中老年FC患者在边缘系统、辅助运动皮层和默认模式网络脑区的节点水平属性存在差异，且ORBmid.R的节点效率与PAC-QoL评分呈正相关，提示FC可能与ORBmid.R中内脏感觉运动的异常处理有关，为中老年FC患者提供了潜在的影像学诊断标志物和治疗靶点。
