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专用腹腔镜设备治疗肝包虫囊肿:一项回顾性分析及文献综述

Specialized Laparoscopic Devices in the Treatment of Hydatic Hepatic Cysts: A Retrospective Analysis and Review of the Literature.

作者信息

Mihetiu Alin, Bratu Dan Georgian, Sandu Alexandra, Sabau Alexandru, Sabau Dan

机构信息

Second Surgical Department, "Lucian Blaga" University of Sibiu, County Clinical Emergency Hospital of Sibiu, Sibiu, ROU.

Faculty of Medicine, "Lucian Blaga" University of Sibiu, Sibiu, ROU.

出版信息

Cureus. 2024 Mar 11;16(3):e55968. doi: 10.7759/cureus.55968. eCollection 2024 Mar.

DOI:10.7759/cureus.55968
PMID:38601419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11006410/
Abstract

Background and objective While hydatid disease is associated with a high prevalence only in certain endemic areas, it can be encountered in any geographical region. The characteristics of this parasitic disease, and its implications during development, such as the risk of seeding, and the complications caused by cyst rupture, means that its therapeutic management should adhere to strict principles and may sometimes require approaches specially tailed for this type of pathology. In this study, we aimed to provide a comparative analysis of conventional laparoscopic techniques vs. treatment with specialized instrumentation in these patients. Methods Our study involved a retrospective evaluation of a cohort comprising 41 patients diagnosed with hepatic hydatid cysts, who underwent procedures with both conventional laparoscopic techniques and specialized instrumentation tailored for this particular pathology. Furthermore, we conducted a comprehensive review of the literature examining alternative types of laparoscopic instrumentation specifically crafted for the management of hydatid cysts. This review employed an extensive search utilizing PubMed and Google Scholar databases. Results The examination of cases within our study revealed a high prevalence of hydatid disease among male patients (63.41%) and a predominance of instances originating from rural regions necessitating emergent admissions (p<0.05). Notably, in 58.54% of cases, surgical interventions employed specialized instrumentation, with a notable discrepancy in conversion rates to open surgery favoring the standard approach: 12.2% vs. 2.44% (p=0.025). Additionally, the laparoscopic approach was associated with prolonged surgical durations compared to the dedicated technique (p=0.002), besides a higher incidence of postoperative complications (12.2% vs 7.32%). Furthermore, patients undergoing laparoscopic procedures with standard instrumentation experienced lengthier hospital stays (p=0.002). Our comprehensive review of the literature identified six distinct surgical methodologies utilizing specifically tailored instrumentation for addressing hydatid cysts. Analysis of these findings underscored a preference for single localizations and selective cases. Postoperative complication rates ranged from 6.66% to 22.22%, with conversion rates to open surgery reaching up to 23.33%, and recurrence rates observed to be as high as 7.81%. Conclusions The patented approach, which uses special trocars that provide stable anchorage and allow a safe puncture-aspiration, reaspiration, and fragmentation processes, has superior characteristics compared to the laparoscopic approach with standard instrumentation. Comparative analysis with other similar procedures described in the literature has shown similar results regarding the frequency of complications, with our technique being superior in terms of approaching multiple cysts and recurrence rate. It has been successfully applied even in unselected cases.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/f590e5474c29/cureus-0016-00000055968-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/8f60fa028ebd/cureus-0016-00000055968-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/c10e23b64d14/cureus-0016-00000055968-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/21b5074e0d25/cureus-0016-00000055968-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/fe5545102390/cureus-0016-00000055968-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/a2818d9538c5/cureus-0016-00000055968-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/f590e5474c29/cureus-0016-00000055968-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/8f60fa028ebd/cureus-0016-00000055968-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/c10e23b64d14/cureus-0016-00000055968-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/21b5074e0d25/cureus-0016-00000055968-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/fe5545102390/cureus-0016-00000055968-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/a2818d9538c5/cureus-0016-00000055968-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e5/11006410/f590e5474c29/cureus-0016-00000055968-i06.jpg
摘要

背景与目的 虽然包虫病仅在某些流行地区具有较高的患病率,但在任何地理区域都可能遇到。这种寄生虫病的特征及其在发展过程中的影响,如播散风险和囊肿破裂引起的并发症,意味着其治疗管理应遵循严格的原则,有时可能需要针对此类病理情况采取专门的方法。在本研究中,我们旨在对这些患者的传统腹腔镜技术与使用专门器械治疗进行比较分析。方法 我们的研究包括对一组41例诊断为肝包虫囊肿的患者进行回顾性评估,这些患者接受了传统腹腔镜技术和针对这种特殊病理情况定制的专门器械的手术。此外,我们对文献进行了全面回顾,研究了专门为处理包虫囊肿而设计的替代类型的腹腔镜器械。该回顾利用PubMed和谷歌学术数据库进行了广泛搜索。结果 我们研究中的病例检查显示,男性患者中包虫病的患病率较高(63.41%),且大多数病例来自农村地区,需要紧急入院(p<0.05)。值得注意的是,在58.54%的病例中,手术干预采用了专门器械,转为开放手术的转化率存在显著差异,有利于标准方法:12.2%对2.44%(p=0.025)。此外,与专门技术相比,腹腔镜方法与手术时间延长相关(p=0.002),术后并发症发生率也更高(12.2%对7.32%)。此外,使用标准器械进行腹腔镜手术的患者住院时间更长(p=0.002)。我们对文献的全面回顾确定了六种不同的手术方法,使用专门定制的器械来处理包虫囊肿。对这些结果的分析强调了对单一部位和选择性病例的偏好。术后并发症发生率在6.66%至22.22%之间,转为开放手术的转化率高达23.33%,复发率高达7.81%。结论 专利方法使用提供稳定锚固并允许安全穿刺抽吸、再抽吸和破碎过程的特殊套管针,与使用标准器械的腹腔镜方法相比具有优越的特性。与文献中描述的其他类似手术的比较分析显示,并发症发生率相似,我们的技术在处理多个囊肿和复发率方面更优越。它甚至已成功应用于未选择的病例。

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World J Gastrointest Surg. 2023 Aug 27;15(8):1591-1599. doi: 10.4240/wjgs.v15.i8.1591.
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Adverse Drug Reactions Relevant to Drug Resistance and Ineffectiveness Associated with Meropenem, Linezolid, and Colistin: An Analysis Based on Spontaneous Reports from the European Pharmacovigilance Database.与美罗培南、利奈唑胺和黏菌素相关的耐药性及无效性的药物不良反应:基于欧洲药物警戒数据库自发报告的分析
Antibiotics (Basel). 2023 May 16;12(5):918. doi: 10.3390/antibiotics12050918.
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Comparison of laparoscopic and open surgery in hepatic hydatid disease in children: Feasibility, efficacy and safety.
儿童肝包虫病腹腔镜手术与开放手术的比较:可行性、疗效及安全性
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Percutaneous Drainage in Hepatic Hydatidosis-The PAIR Technique: Concept, Technique, and Results.肝包虫病的经皮引流——穿刺、抽吸、注射、再抽吸技术:概念、技术及结果
J Clin Exp Hepatol. 2021 Sep-Oct;11(5):592-602. doi: 10.1016/j.jceh.2021.05.005. Epub 2021 May 26.
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The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.《PRISMA 2020声明:报告系统评价的更新指南》
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Gastroenterol Hepatol. 2018 Oct;41(8):532-534. doi: 10.1016/j.gastrohep.2018.06.002. Epub 2018 Jul 20.
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Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets.人包虫病(囊型和泡型)的药物治疗进展:化合物和治疗靶点。
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