Gao Fei-Fei, Chen Dian-Qing, Jiang Yue-Tong, Han Cui-Fei, Lin Bi-Yun, Yang Zhan, Quan Juan-Hua, Xiong Ying-Huan, Chen Xin-Tian
Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Department of Hand and Foot Surgery, Armed Police Corps Hospital of Hebei, Shijiazhuang, Hebei, China.
Front Pharmacol. 2024 Mar 27;15:1354806. doi: 10.3389/fphar.2024.1354806. eCollection 2024.
Lung injury leads to respiratory dysfunction, low quality of life, and even life-threatening conditions. Circular RNAs (circRNAs) are endogenous RNAs produced by selective RNA splicing. Studies have reported their involvement in the progression of lung injury. Understanding the roles of circRNAs in lung injury may aid in elucidating the underlying mechanisms and provide new therapeutic targets. Thus, in this review, we aimed to summarize and discuss the characteristics and biological functions of circRNAs, and their roles in lung injury from existing research, to provide a theoretical basis for the use of circRNAs as a diagnostic and therapeutic target for lung injury.
肺损伤会导致呼吸功能障碍、生活质量下降，甚至危及生命。环状RNA（circRNAs）是由选择性RNA剪接产生的内源性RNA。研究报道它们参与了肺损伤的进展。了解circRNAs在肺损伤中的作用可能有助于阐明其潜在机制，并提供新的治疗靶点。因此，在本综述中，我们旨在总结和讨论circRNAs的特征和生物学功能，以及它们在现有研究中在肺损伤中的作用，为将circRNAs用作肺损伤的诊断和治疗靶点提供理论依据。
