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肥胖患者的单髁膝关节置换术,15年生存率较低。

Unicompartmental knee arthroplasty in obese patients, poorer survivorship at 15 years.

作者信息

Lee Hong Jing, Xu Sheng, Liow Ming Han Lincoln, Pang Hee Nee, Tay Darren Keng-Jin, Yeo Seng Jin, Lo Ngai Nung, Chen Jerry Yongqiang

机构信息

Lee Kong Chian School of Medicine, Nanyang Technological University, Headquarters & Clinical Sciences Building 11, Mandalay Road, Singapore, 308232, Singapore.

Department of Orthopaedic Surgery, Singapore General Hospital, 20 College Road, Academia Level 4, Singapore, 169856, Singapore.

出版信息

J Orthop. 2024 Apr 2;53:156-162. doi: 10.1016/j.jor.2024.04.001. eCollection 2024 Jul.

Abstract

INTRODUCTION

The preclusion of obese patients from unicompartmental knee arthroplasty (UKA) has increasingly been challenged. This study aimed to evaluate the impact of Body Mass Index (BMI) on UKA at 15-year follow-up.

MATERIALS AND METHODS

169 unilateral UKA patients from 2003 to 2007 were followed-up prospectively for at least 15 years. 70 patients were left for analysis after accounting for patient demise, revision surgery and loss to follow-up. 48 of these patients (69%) were in the Control group (BMI <30 kg/m) and 22 (31%) were in the Obese group (BMI ≥30 kg/m). Patients were assessed before and after operation using the Knee Society Function Score (KSFS), Knee Society Knee Score (KSKS), Oxford Knee Score (OKS), and Physical (PCS) and Mental (MCS) component of the Short Form 12. Survivorship analysis was also performed.

RESULTS

Obese patients went through UKA at an earlier age than the non-obese patients (54.7 ± 4.7 years compared to 59.9 ± 7.8 years, p = 0.005). At 2, 10, and 15-year follow-up, both groups achieved clinically significant improvements in outcomes. There was no significant association found between obesity and outcome using multiple linear regression. While propensity matching found PCS improvement at 2 years to be greater in obese patients, no significant association between obesity and 15-year outcome was found. All 13 patients who required revision, underwent total knee arthroplasty (TKA). The overall 15-year survivorship was 74.2% within the obese group and 92.4% within the control group.

CONCLUSION

Compared to non-obese patients, obese patients had poorer 15-year survivorship with greater odds of requiring revision surgery. However, assuming implant survival, obese patients can expect a non-inferior outcome relative to their non-obese counterparts in all patient reported outcome measures 15 years after surgery.

摘要

引言

肥胖患者被排除在单髁膝关节置换术(UKA)之外的情况越来越受到挑战。本研究旨在评估体重指数(BMI)对UKA术后15年随访结果的影响。

材料与方法

对2003年至2007年的169例单侧UKA患者进行了至少15年的前瞻性随访。在考虑患者死亡、翻修手术和失访情况后,留下70例患者进行分析。其中48例患者(69%)属于对照组(BMI<30kg/m²),22例(31%)属于肥胖组(BMI≥30kg/m²)。术前和术后使用膝关节协会功能评分(KSFS)、膝关节协会膝关节评分(KSKS)、牛津膝关节评分(OKS)以及简短健康调查问卷12的身体(PCS)和精神(MCS)分量表对患者进行评估。还进行了生存率分析。

结果

肥胖患者接受UKA手术的年龄比非肥胖患者早(分别为54.7±4.7岁和59.9±7.8岁,p=0.005)。在2年、10年和15年的随访中,两组患者的各项指标均取得了具有临床意义的改善。多元线性回归分析未发现肥胖与预后之间存在显著关联。虽然倾向匹配法发现肥胖患者在术后2年的PCS改善更大,但未发现肥胖与15年预后之间存在显著关联。所有13例需要翻修的患者均接受了全膝关节置换术(TKA)。肥胖组的15年总体生存率为74.2%,对照组为92.4%。

结论

与非肥胖患者相比,肥胖患者15年生存率较低,翻修手术的可能性更大。然而,假设植入物存活,肥胖患者在术后15年的所有患者报告结局指标方面,预期结果并不逊于非肥胖患者。

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