College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.
Laoshan Laboratory, Qingdao 266237, P. R. China.
Chem Commun (Camb). 2024 Apr 30;60(36):4773-4776. doi: 10.1039/d4cc00760c.
A small-molecule Fenton reagent, integrating ferrocene with a carbonic anhydrase inhibitor, was designed to intelligently regulate intracellular acidosis for self-augmented chemodynamic therapy. Acidosis coupled with up-regulated ROS levels demonstrated potent cytotoxicity and effective tumor suppression.
一种小分子芬顿试剂，将二茂铁与碳酸酐酶抑制剂结合，旨在智能调节细胞内酸中毒以实现自我增强的化学动力学治疗。酸中毒与上调的 ROS 水平相结合，表现出强大的细胞毒性和有效的肿瘤抑制作用。
