Medical Imaging Techniques Program, Vocational School of Health Services, Bursa Uludag University, Bursa 16059, Turkey.
Department of Radiology, Faculty of Medicine, Bursa Uludag University, Bursa 16059, Turkey.
Cereb Cortex. 2024 Apr 1;34(4). doi: 10.1093/cercor/bhae142.
Studies of the development and asymmetry of the corpus striatum and thalamus in early childhood are rare. Studies investigating these structures across the lifespan have not presented their changes during childhood and adolescence in detail. For these reasons, this study investigated the effect of age and sex factors on the development and asymmetry of the corpus striatum and thalamus in the 1-18 age group. In this retrospective study, we included 652 individuals [362 (56%) males] aged 1-18 years with normal brain MRI between 2012 and 2021. Absolute and relative volumes of the corpus striatum and thalamus were obtained by segmentation of three-dimensional T1-weighted MRIs with volBrain1.0. We created age-specific volume data and month-based development models with the help of SPSS (ver.28). The corpus striatum and thalamus had cubic absolute volumetric developmental models. The relative volume of the caudate and thalamus (only males) is consistent with the decreasing "growth" model, the others with the decreasing cubic model. The absolute volumes of the males' bilateral corpus striatum and thalamus and the relative volumes of the caudate and thalamus of the females were significantly larger (P < 0.05). The caudate showed right > left lateralization; putamen, globus pallidus, and thalamus showed left > right lateralization.
在儿童早期，对纹状体和丘脑的发育和不对称性的研究很少。研究这些结构在整个生命周期的变化的研究并没有详细描述其在儿童和青少年时期的变化。出于这些原因，本研究调查了年龄和性别因素对 1-18 岁年龄组纹状体和丘脑发育和不对称性的影响。在这项回顾性研究中，我们纳入了 2012 年至 2021 年间的 652 名正常脑 MRI 的个体[362 名（56%）男性，年龄 1-18 岁]。使用 volBrain1.0 对三维 T1 加权 MRI 进行分割，获得纹状体和丘脑的绝对和相对体积。我们借助 SPSS（版本 28）创建了特定年龄的体积数据和基于月份的发育模型。纹状体和丘脑具有立方绝对体积发育模型。尾状核和丘脑（仅男性）的相对体积符合递减“生长”模型，其他符合递减立方模型。男性双侧纹状体和丘脑的绝对体积以及女性尾状核和丘脑的相对体积明显更大（P<0.05）。尾状核显示右侧>左侧偏侧化；壳核、苍白球和丘脑显示左侧>右侧偏侧化。
