Langford Vets, University of Bristol, Langford BS40 5DU, United Kingdom; Bristol Veterinary School, University of Bristol, Langford BS40 5DU, United Kingdom.
Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, United Kingdom.
Vet J. 2024 Jun;305:106111. doi: 10.1016/j.tvjl.2024.106111. Epub 2024 Apr 9.
Canine mycobacterial disease was first recognised over 100 years ago but is now an emerging concern. All reported cases of tuberculous disease in dogs have been caused by infection with one of three Mycobacterium tuberculosis-complex (MTBC) organisms (M. tuberculosis, Mycobacterium bovis, and Mycobacterium microti). Molecular PCR and interferon-gamma release assays offer alternative or complementary diagnostic pathways to that of specialist culture, which is limited by availability, sensitivity, and the time it takes to get a result. Optimised triple antimicrobial protocols offer an excellent chance of a successful outcome in dogs where treatment can be considered and is attempted. In this review, the clinical presentation, diagnosis, treatment, and prognosis of canine tuberculosis are discussed.
犬分枝杆菌病早在 100 多年前就已被认识，但现在仍是一个新出现的问题。所有报告的犬结核病病例都是由三种结核分枝杆菌复合群（MTBC）病原体（结核分枝杆菌、牛分枝杆菌和微小分枝杆菌）感染引起的。分子 PCR 和干扰素-γ释放试验为专门培养提供了替代或补充的诊断途径，而专门培养受到可用性、敏感性和获得结果所需时间的限制。优化的三联抗微生物方案为可考虑并尝试治疗的犬提供了极好的成功机会。在这篇综述中，讨论了犬结核病的临床表现、诊断、治疗和预后。
