[Seroprevalence of the specific antibody against among patients with hematological diseases].

OBJECTIVE

To investigate the seroprevalence of infections among patients with hematological diseases, so as to provide insights into improving the prognosis and quality of life among patients with hematological diseases.

METHODS

A total of 240 patients with hematological diseases (including 170 patients with hematological tumors and 70 patients with non-tumor hematological diseases) admitted to The Affiliated Hospital of Putian University during the period from January 1, 2021 through October 10, 2023 and 500 healthy volunteers in the hospital during the same period were enrolled. Subjects' demographics and serum samples were collected, and serum specific IgG and IgM antibodies against were detected using the chemiluminescence assay, with any of a positive IgG or IgM antibody defined as a positive infection. The seroprevalence of specific IgG and IgM antibodies against was compared between patients with hematological diseases and healthy volunteers.

RESULTS

The mean age ( = 2.034, > 0.05) and gender distribution (χ = 0.462, > 0.05) were comparable among patients with hematological tumors, patients with non-tumor hematological diseases and healthy volunteers, and there was no significant difference in the proportion of history of cat or dog contacts between patients with hematological diseases and healthy volunteers (χ = 0, > 0.05). The seroprevalence of anti- antibody was significantly higher among patients with hematological diseases than among healthy volunteers (15.8% vs. 0.6%; χ = 71.902, < 0.01), and there was a significant difference in the seroprevalence of anti- antibody among patients with hematological tumors (18.2%), patients with non-tumor hematological diseases (10.0%) and healthy volunteers (χ = 78.327, < 0.01). The seroprevalence of anti- antibody was significantly higher among patients with hematological tumors and non-tumor hematological diseases than among healthy volunteers (both values < 0.05), while no significant difference was seen in the seroprevalence of anti- antibody between patients with hematological tumors and non-tumor hematological diseases ( > 0.05). In addition, the proportion of history of cat or dog contacts was significantly higher among patients with hematological diseases that were positive for serum anti- anti-body than among those negative for serum anti- antibody (21.1% vs. 5.4%; χ = 8.653, < 0.05).

CONCLUSIONS

There is a high seroprevalene rate of infections among hematological diseases, which is significantly greater than that among healthy volunteers.