Gan D, Fan J, Zeng J, Lin J, Chen X
Department of Hematology, The Affiliated Hospital of Putian University, Putian, Fujian 351100, China.
Department of Clinical Laboratory, The Affiliated Hospital of Putian University, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2023 Dec 25;36(1):83-86. doi: 10.16250/j.32.1374.2023197.
To investigate the seroprevalence of infections among patients with hematological diseases, so as to provide insights into improving the prognosis and quality of life among patients with hematological diseases.
A total of 240 patients with hematological diseases (including 170 patients with hematological tumors and 70 patients with non-tumor hematological diseases) admitted to The Affiliated Hospital of Putian University during the period from January 1, 2021 through October 10, 2023 and 500 healthy volunteers in the hospital during the same period were enrolled. Subjects' demographics and serum samples were collected, and serum specific IgG and IgM antibodies against were detected using the chemiluminescence assay, with any of a positive IgG or IgM antibody defined as a positive infection. The seroprevalence of specific IgG and IgM antibodies against was compared between patients with hematological diseases and healthy volunteers.
The mean age ( = 2.034, > 0.05) and gender distribution (χ = 0.462, > 0.05) were comparable among patients with hematological tumors, patients with non-tumor hematological diseases and healthy volunteers, and there was no significant difference in the proportion of history of cat or dog contacts between patients with hematological diseases and healthy volunteers (χ = 0, > 0.05). The seroprevalence of anti- antibody was significantly higher among patients with hematological diseases than among healthy volunteers (15.8% vs. 0.6%; χ = 71.902, < 0.01), and there was a significant difference in the seroprevalence of anti- antibody among patients with hematological tumors (18.2%), patients with non-tumor hematological diseases (10.0%) and healthy volunteers (χ = 78.327, < 0.01). The seroprevalence of anti- antibody was significantly higher among patients with hematological tumors and non-tumor hematological diseases than among healthy volunteers (both values < 0.05), while no significant difference was seen in the seroprevalence of anti- antibody between patients with hematological tumors and non-tumor hematological diseases ( > 0.05). In addition, the proportion of history of cat or dog contacts was significantly higher among patients with hematological diseases that were positive for serum anti- anti-body than among those negative for serum anti- antibody (21.1% vs. 5.4%; χ = 8.653, < 0.05).
There is a high seroprevalene rate of infections among hematological diseases, which is significantly greater than that among healthy volunteers.
调查血液系统疾病患者中感染的血清流行率，以便为改善血液系统疾病患者的预后和生活质量提供见解。
纳入2021年1月1日至2023年10月10日期间在莆田学院附属医院住院的240例血液系统疾病患者（包括170例血液系统肿瘤患者和70例非肿瘤性血液系统疾病患者）以及同期在该院的500名健康志愿者。收集受试者的人口统计学资料和血清样本，采用化学发光法检测血清中针对的特异性IgG和IgM抗体，IgG或IgM抗体任何一项阳性定义为感染阳性。比较血液系统疾病患者和健康志愿者中针对的特异性IgG和IgM抗体的血清流行率。
血液系统肿瘤患者、非肿瘤性血液系统疾病患者和健康志愿者的平均年龄（=2.034，>0.05）和性别分布（χ=0.462，>0.05）具有可比性，血液系统疾病患者和健康志愿者之间猫或狗接触史的比例无显著差异（χ=0，>0.05）。血液系统疾病患者中抗抗体的血清流行率显著高于健康志愿者（15.8%对0.6%；χ=71.902，<0.01），血液系统肿瘤患者（18.2%）、非肿瘤性血液系统疾病患者（10.0%）和健康志愿者中抗抗体的血清流行率存在显著差异（χ=78.327，<0.01）。血液系统肿瘤患者和非肿瘤性血液系统疾病患者中抗抗体的血清流行率均显著高于健康志愿者（均<0.05），而血液系统肿瘤患者和非肿瘤性血液系统疾病患者之间抗抗体的血清流行率无显著差异（>0.05）。此外，血清抗抗体阳性的血液系统疾病患者中猫或狗接触史的比例显著高于血清抗抗体阴性的患者（21.1%对5.4%；χ=8.653，<0.05）。
血液系统疾病患者中感染的血清流行率较高，显著高于健康志愿者。
