Ding Huan, Gao Yu-Meng, Deng Yao, Lamberton Poppy H L, Lu Da-Bing
Department of Epidemiology and Statistics, School of Public Health, Soochow University, Suzhou, 215123, China.
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, 215123, People's Republic of China.
Parasit Vectors. 2017 Jan 13;10(1):27. doi: 10.1186/s13071-017-1970-6.
Toxoplasmosis is caused by Toxoplasma gondii which can infect all warm-blooded animals. As the most common feline definitive host, cats play a vital role in the transmission of T. gondii. However, national estimates of the seroprevalence of T. gondii in cats in mainland China are lacking, and therefore a systematic review and meta-analysis were performed to provide insight into national environmental transmission levels and potential transmission to humans.
Studies published up until July 1, 2016, on T. gondii seroprevalence in cats within mainland China were searched for in CNKI, WanFang, CBM, PubMed, Embase and through the reference lists of resulting articles. The seroprevalence with its 95% confidence interval (CI) for each individual study was presented, and then point estimates and their 95% confidence intervals (CIs) of pooled seroprevalence were calculated. Subgroup analyses were performed according to potential risk factors.
A total of 38 eligible studies, published between 1995 to 2016, covering fifteen provinces and municipalities, and involving 7,285 cats, were included. The seroprevalence in cats per study ranged from 3.9 to 79.4% with a median of 20.3%. As substantial heterogeneity existed among studies, a random-effects model was used to estimate the pooled seroprevalence. The value of the point estimate seroprevalence was 24.5% (95% CI: 20.1-29.0). Seroprevalence in stray cats was significantly higher than in pet cats (OR = 3.00, 95% CI: 1.60-5.64). The seroprevalence increased significantly with cat age (P = 0.018) with 17.4% (95% CI: 7.6-27.2) in the group of ≤ 1 year old, 19.5% (95% CI: 12.7-26.3) in the group of ≤ 3 year-old and 31.6% (95% CI: 22.9-40.3) in the group of > 3 year-old.
The seroprevalence of T. gondii in cats in mainland China was moderate and was associated with cat ownership and age. Due to the increasing prevalence of pet cats in China and the intimate relationship between these cats and humans, this might present a significant exposure risk, particularly for China's large susceptible population. Therefore, further research is needed into the links between cat ownership and human T. gondii infection and how to reduce T. gondii exposure in humans via cat contacts and the environmental contamination with T. gondii oocysts by cats.
弓形虫病由刚地弓形虫引起，可感染所有温血动物。猫作为最常见的终末宿主，在刚地弓形虫的传播中起着至关重要的作用。然而，中国大陆地区缺乏猫弓形虫血清阳性率的全国性估计，因此进行了一项系统评价和荟萃分析，以深入了解全国环境传播水平以及对人类的潜在传播情况。
在知网、万方、中国生物医学文献数据库、PubMed、Embase中检索截至2016年7月1日发表的关于中国大陆地区猫弓形虫血清阳性率的研究，并通过所得文章的参考文献列表进行查找。呈现每项单独研究的血清阳性率及其95%置信区间（CI），然后计算合并血清阳性率的点估计值及其95%置信区间（CI）。根据潜在危险因素进行亚组分析。
共纳入38项符合条件的研究，这些研究发表于1995年至2016年之间，覆盖15个省和直辖市，涉及7285只猫。每项研究中猫的血清阳性率范围为3.9%至79.4%，中位数为20.3%。由于研究之间存在显著异质性，采用随机效应模型估计合并血清阳性率。点估计血清阳性率值为24.5%（95%CI：20.1 - 29.0）。流浪猫的血清阳性率显著高于宠物猫（OR = 3.00，95%CI：1.60 - 5.64）。血清阳性率随猫龄显著增加（P = 0.018），≤1岁组为17.4%（95%CI：7.6 - 27.2），≤3岁组为19.5%（95%CI：12.7 - 26.3），>3岁组为
