Department of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, 74 Lin Jiang Road, Chongqing, 40010, China.
Department of Mechanical Engineering, Chongqing University of Technology, No. 69 Hongguang Avenue, Chongqing, 400054, China.
Trials. 2024 Apr 11;25(1):254. doi: 10.1186/s13063-024-08081-1.
Research to date has lacked definitive evidence to determine whether mirror therapy promotes the recovery of upper extremity function after stroke. Considering that previous studies did not stratify patients based on structural retention, this may be one of the reasons for the negative results obtained in many trials. The goal evaluates the efficacy of TBMT (utilizing an innovatively designed mirror) versus standard occupational therapy for stroke patient's upper limb functionality.
This single-center randomized controlled trial will involve 50 patients with stroke. All patients will be randomly assigned to either the task-based mirror therapy or the control group. The interventions will be performed 5 days per week for 4 weeks. The primary outcomes will be the mean change in scores on both the FMA-UE and modified Barthel Index (MBI) from baseline to 4 weeks intervention and at 12 weeks follow-up between the two groups and within groups. The other outcomes will include the Action Research Arm Test (ARAT), the Nine Hole Peg Test (9HPT), the Functional Independence Measure, and MRI.
This trial will not only to establish that task-based mirror therapy (TBMT) could improve the recovery of hand function after stroke but also to explore the underlying mechanisms. We expect that this finding will clarify the brain activation and brain network mechanisms underlying the improvement of hand function with task-oriented mirror therapy and lead to new ideas for stroke hand function rehabilitation.
URL: https://www.chictr.org.cn ; Unique identifier: ChiCTR2300068855. Registered on March 1, 2023.
迄今为止的研究缺乏确凿的证据来确定镜像疗法是否能促进中风后上肢功能的恢复。考虑到之前的研究没有根据结构保留对患者进行分层，这可能是许多试验得出负面结果的原因之一。本研究旨在评估基于任务的镜像疗法（使用创新设计的镜子）与标准作业疗法治疗中风患者上肢功能的疗效。
这是一项单中心随机对照试验，将纳入 50 名中风患者。所有患者将随机分为基于任务的镜像治疗组或对照组。干预措施将在每周 5 天进行，持续 4 周。主要结局将是两组之间以及组内从基线到 4 周干预和 12 周随访时 FMA-UE 和改良巴氏指数（MBI）的平均变化。其他结局包括动作研究上肢测试（ARAT）、九孔钉测试（9HPT）、功能独立性测量和 MRI。
本试验不仅将证实基于任务的镜像疗法（TBMT）可以改善中风后手功能的恢复，还将探索其潜在机制。我们期望这一发现将阐明基于任务的镜像治疗改善手功能的大脑激活和脑网络机制，并为中风手功能康复带来新的思路。
网址：https://www.chictr.org.cn；唯一标识符：ChiCTR2300068855。注册于 2023 年 3 月 1 日。
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