一种新型膝关节骨关节炎超声影像学指标的诊断准确性：敏感性、特异性和预测值评估。
Diagnostic accuracy of a novel ultrasound imaging index for knee osteoarthritis: Evaluation of sensitivity, specificity, and predictive values.
机构信息
Department of Radiology, Medical Corporation Seireikai Tachikawa Memorial Hospital, Kasama, Ibaraki, Japan.
Graduate School of Medicine, Suzuka University of Medical Science, Suzuka-shi, Mie, Japan.
出版信息
J Clin Ultrasound. 2024 Jul-Aug;52(6):687-699. doi: 10.1002/jcu.23691. Epub 2024 Apr 12.
PURPOSE
We aimed to develop and validate a new ultrasonography (US) index for the diagnosis of primary medial-type knee osteoarthritis (OA).
METHODS
In total, 156 patients (203 limbs) underwent standing knee radiography and the US for suspected knee OA. Total osteophyte height (TOH) and distance between bones (DBB) aided diagnosis. Logistic regression identified optimal cutoff values. Thresholds from logistic regression informed recipient operating characteristic curve (ROC) analysis, balancing sensitivity and specificity. These thresholds were then applied in the differential thermal analysis (DTA) to construct a 2 × 2 table.
RESULTS
The TOH-DBB index showed that a DBB of 5.6 mm or less was required to diagnose primary medial-type knee arthropathy. The results in the 2 × 2 table were 41 true-positive (TP), 10 false negative (FN), 22 true-negative (TN), and 7 false positive (FP). A DBB of 5.6 mm or less and TOH of 4.7 mm or more were necessary to diagnose severe deformity. The results in the 2 × 2 table were 10 TP, 4 FN, 23 TN, and 4 FP.
CONCLUSION
The TOH-DBB index was confirmed to capture changes in primary medial-type knee OA across various stages.
目的
我们旨在开发和验证一种新的超声（US）指数，用于诊断原发性内侧型膝关节骨关节炎（OA）。
方法
共有 156 名患者（203 条肢体）接受了站立膝关节放射摄影和疑似膝关节 OA 的 US 检查。总骨赘高度（TOH）和骨间距离（DBB）辅助诊断。逻辑回归确定了最佳截断值。逻辑回归的阈值告知了接受者操作特征曲线（ROC）分析，平衡了敏感性和特异性。这些阈值随后应用于差示热分析（DTA）中，以构建一个 2×2 表。
结果
TOH-DBB 指数表明，需要 DBB 为 5.6mm 或更小时才能诊断原发性内侧型膝关节关节炎。2×2 表中的结果为 41 个真阳性（TP）、10 个假阴性（FN）、22 个真阴性（TN）和 7 个假阳性（FP）。DBB 为 5.6mm 或更小时，TOH 为 4.7mm 或更大时，需要诊断严重畸形。2×2 表中的结果为 10 个 TP、4 个 FN、23 个 TN 和 4 个 FP。
结论
TOH-DBB 指数被证实可以捕捉原发性内侧型膝关节 OA 在不同阶段的变化。
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