Department of Pharmaceutics and Biopharmacy, Philipps-Universität, Marburg, Germany; Medical Clinic II, Department of Internal Medicine, Justus-Liebig-Universität, Giessen, Germany.
Colloids Surf B Biointerfaces. 2024 Jun;238:113886. doi: 10.1016/j.colsurfb.2024.113886. Epub 2024 Apr 1.
In this work, poly(lactide) nanoparticles were equipped with a bioinspired coating layer based on poly[2-(methacryloyloxy)ethyl phosphorylcholine] and then evaluated when administered to the lungs and after intravenous injection. Compared to the plain counterparts, the chosen zwitterionic polymer shell prevented the coated colloidal formulation from aggregation and conditioned it for lower cytotoxicity, protein adsorption, complement activation and phagocytic cell uptake. Consequently, no interference with the biophysical function of the lung surfactant system could be detected accompanied by negligible protein and cell influx into the bronchoalveolar space after intratracheal administration. When injected into the central compartment, the coated formulation showed a prolonged circulation half-life and a delayed biodistribution to the liver. Taken together, colloidal drug delivery vehicles would clearly benefit from the investigated poly[2-(methacryloyloxy)ethyl phosphorylcholine]-based polymer coatings.
在这项工作中，聚（丙交酯）纳米粒子被装备上了基于聚[2-（甲基丙烯酰氧基）乙基磷酸胆碱]的仿生涂层，然后对其肺部给药和静脉注射后的情况进行了评估。与普通的纳米粒子相比，选择的两性离子聚合物外壳防止了包裹的胶体制剂聚集，并使其具有更低的细胞毒性、蛋白质吸附、补体激活和吞噬细胞摄取。因此，在气管内给药后，没有检测到对肺表面活性剂系统的生物物理功能的干扰，同时进入支气管肺泡腔的蛋白质和细胞也很少。当注入中央隔室时，涂层制剂表现出延长的循环半衰期和延迟的向肝脏的生物分布。总的来说，胶体药物递送载体将明显受益于所研究的基于聚[2-（甲基丙烯酰氧基）乙基磷酸胆碱]的聚合物涂层。
