Department of Community Medicine, The Arctic University of Norway, Norway.
Regional Centre for Child and Youth Mental Health and Child Welfare, IPH, NTNU, Trondheim, Norway.
J Affect Disord. 2024 Jul 1;356:628-638. doi: 10.1016/j.jad.2024.04.037. Epub 2024 Apr 10.
Coronavirus Disease 2019 (COVID-19), a highly contagious respiratory illnesses, has globally impacted mental health. This study aims to investigate the association between intolerance of uncertainty and depressive symptoms during the pandemic in New York, USA, considering COVID-19-related worries as modifiers and mediators.
1227 participants from three ongoing cohort studies, originally centered on trauma-exposed children and adolescents, provided data via questionnaires and telephone interviews across three waves. We used multivariable logistic and linear regression models to investigate the intolerance of uncertainty-depressive symptoms relationship, while adjusting for potential confounders and assessing the modification and mediation effects of Covid-19 related worries.
Depressive symptoms prevalence was 18 %, 12 %, and 9 % at waves 0, 1, and 2 respectively. Strong positive associations were observed between intolerance of uncertainty above the median and depressive symptoms which remained significant after adjusting for potential confounders. Odds ratios were 2.14 (95 % CI: 1.54-2.99) and 4.50 (95 % CI: 2.67-7.93) for intolerance of uncertainty-depressive symptoms association at wave 0 and 1 respectively, and 3.22 (95 % CI: 1.68-6.63) for intolerance of uncertainty at wave 1 and depressive symptoms at wave 2. There was evidence of partial mediation by worries (12-37 %), but no evidence of a moderating effect.
It includes study's methodology, including self-report measures, remote data collection, and uncontrolled variables like anxiety and COVID-19 perspectives.
The findings emphasize the importance of evidence-based strategies for tackling intolerance of uncertainty during pandemics, particularly in managing long COVID. Collaborative efforts between policymakers and clinicians are essential in this endeavor.
新型冠状病毒病 2019（COVID-19）是一种高度传染性的呼吸道疾病，已对全球的心理健康产生影响。本研究旨在调查美国纽约在大流行期间，无法忍受不确定性与抑郁症状之间的关系，同时将 COVID-19 相关担忧视为调节因素和中介因素。
三个正在进行的队列研究的 1227 名参与者，最初的研究重点是创伤暴露的儿童和青少年，他们通过问卷调查和电话访谈在三个波次中提供数据。我们使用多变量逻辑回归和线性回归模型来研究无法忍受不确定性与抑郁症状之间的关系，同时调整潜在的混杂因素，并评估 COVID-19 相关担忧的调节和中介效应。
抑郁症状的患病率在波次 0、1 和 2 分别为 18%、12%和 9%。在调整潜在混杂因素后，无法忍受不确定性高于中位数与抑郁症状之间存在强烈的正相关关系。无法忍受不确定性与抑郁症状的比值比分别为 2.14（95%置信区间：1.54-2.99）和 4.50（95%置信区间：2.67-7.93），在波次 0 和 1 时分别为 3.22（95%置信区间：1.68-6.63）。担忧有部分中介作用（12-37%），但没有调节作用的证据。
研究方法包括研究的局限性，包括自我报告测量、远程数据收集以及焦虑和 COVID-19 观点等未控制的变量。
这些发现强调了在大流行期间，特别是在管理长 COVID 时，采用基于证据的策略来解决无法忍受不确定性的重要性。政策制定者和临床医生之间的合作努力在这方面至关重要。
