Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, India.
Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, India; Department of Zoology, Deshbandhu College, University of Delhi, Delhi, India.
Crit Rev Oncol Hematol. 2024 May;197:104346. doi: 10.1016/j.critrevonc.2024.104346. Epub 2024 Apr 10.
Cervical cancer (CaCx) ranks as the fourth most prevalent cancer among women globally. Persistent infection of high-risk human papillomaviruses (HR-HPVs) is major etiological factor associated with CaCx. Signal Transducer and Activator of Transcription 3 (STAT3), a prominent member of the STAT family, has emerged as independent oncogenic driver. It is a target of many oncogenic viruses including HPV. How STAT3 influences HPV viral gene expression or gets affected by HPV is an area of active investigation. A better understanding of host-virus interaction will provide a prognostic and therapeutic window for CaCx control and management. In this comprehensive review, we delve into carcinogenic role of STAT3 in development of HPV-induced CaCx. With an emphasis on fascinating interplay between STAT3 and HPV genome, the review explores the diverse array of opportunities and challenges associated with this field to harness the prognostic and therapeutic potential of STAT3 in CaCx.
宫颈癌（CaCx）是全球女性中第四大常见癌症。高危型人乳头瘤病毒（HR-HPV）的持续感染是与 CaCx 相关的主要病因。信号转导和转录激活因子 3（STAT3）是 STAT 家族中的重要成员，它已成为独立的致癌驱动因素。它是包括 HPV 在内的许多致癌病毒的靶点。STAT3 如何影响 HPV 病毒基因表达或受 HPV 影响是一个活跃的研究领域。更好地了解宿主-病毒相互作用将为 CaCx 的控制和管理提供预后和治疗窗口。在这篇全面的综述中，我们深入探讨了 STAT3 在 HPV 诱导的 CaCx 发展中的致癌作用。重点介绍了 STAT3 和 HPV 基因组之间的迷人相互作用，该综述探讨了该领域与 STAT3 在 CaCx 中的预后和治疗潜力相关的各种机会和挑战。
