Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel; The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel; The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel; Meuhedet HMO, Israel.
Diabetes Res Clin Pract. 2024 May;211:111659. doi: 10.1016/j.diabres.2024.111659. Epub 2024 Apr 11.
To evaluate the risk of type 2 diabetes(T2D) following one abnormal value(OAbV) in an oral glucose tolerance test(oGTT) performed during pregnancy.
A retrospective analysis of parturients between 01.01.2017 and 31.12.2020 with 5 years of follow-up after delivery. Glucose levels during pregnancy were extracted from the computerized laboratory system of Meuhedet HMO and cross-tabulated with the Israeli National Registry of Diabetes. Women with multiple gestations or pregestational diabetes were excluded. Maternal characteristics and risk of T2D were stratified and compared between 3 groups: normal glucose status, OAbV in oGTT, and gestational diabetes. Statistical analysis included univariate analysis followed by survival analysis. Further analysis was stratified to women with and without obesity.
58,693 women entered the analysis. Following an adjustment to maternal age, obesity, hypertension, and hyperlipidemia, OAbV in oGTT was associated with a 1.8-fold increased risk of T2D in a 5-year follow-up compared to normal glucose status. When stratified by obesity, OAbV was associated with a 3.7-fold increase in T2D in women without obesity, however, was no longer a statistically significant predictor of T2D among women with obesity.
Women with OAbV oGTT during pregnancy are at increased risk for developing T2D over 5 years of follow-up.
评估妊娠期口服葡萄糖耐量试验（oGTT）单次异常值（OAbV）后 2 型糖尿病（T2D）的发病风险。
这是一项回顾性分析，纳入了 2017 年 1 月 1 日至 2020 年 12 月 31 日期间的产妇，产后随访时间为 5 年。从 Meuhedet HMO 的计算机化实验室系统中提取妊娠期间的血糖水平，并与以色列国家糖尿病登记处进行交叉制表。排除多胎妊娠或孕前糖尿病的女性。对具有正常葡萄糖状态、oGTT 中的 OAbV 和妊娠期糖尿病的 3 组女性进行分层，并比较其母体特征和 T2D 发病风险。统计分析包括单变量分析和生存分析。进一步的分析分为肥胖和非肥胖的女性。
58693 名女性进入分析。在调整了母亲的年龄、肥胖、高血压和高脂血症后，与正常葡萄糖状态相比，oGTT 中的 OAbV 在 5 年的随访中与 T2D 发病风险增加 1.8 倍相关。按肥胖分层后，OAbV 与非肥胖女性的 T2D 风险增加 3.7 倍相关，但在肥胖女性中不再是 T2D 的统计学显著预测因子。
妊娠期 oGTT 中存在 OAbV 的女性在 5 年的随访中发生 T2D 的风险增加。
