二噁英诱导的细胞色素P-450基因家族在中国仓鼠4号染色体上的定位。
Assignment of dioxin-inducible cytochrome P-450 gene family to Chinese hamster chromosome 4.
作者信息
Hildebrand C E, Stallings R L, Gonzalez F J, Nebert D W
出版信息
Somat Cell Mol Genet. 1985 Jul;11(4):391-5. doi: 10.1007/BF01534416.
The 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P-450 gene family (P1-450 and P3-450 in the C57BL/6N mouse) has recently been localized to mouse chromosome 9. In the present study, HindIII-digested DNA from Chinese hamster, mouse, and 20 Chinese hamster X mouse somatic cell hybrids and subclones segregating hamster chromosomes was probed with the mouse P1-450 and P3-450 full-length cDNA clones. Hamster P-450 gene fragments (6.0 and 7.4 kb) were assigned to Chinese hamster chromosome 4. These data are consistent with linkage conservation among these two P-450 sequences and four other loci on mouse chromosome 9 that map to hamster chromosome 4.
2,3,7,8-四氯二苯并对二恶英诱导的细胞色素P-450基因家族（C57BL/6N小鼠中的P1-450和P3-450）最近已定位到小鼠9号染色体上。在本研究中，用小鼠P1-450和P3-450全长cDNA克隆探测了来自中国仓鼠、小鼠以及20个中国仓鼠×小鼠体细胞杂种和分离仓鼠染色体的亚克隆的经HindIII消化的DNA。仓鼠P-450基因片段（6.0和7.4 kb）被定位到中国仓鼠4号染色体上。这些数据与这两个P-450序列以及小鼠9号染色体上另外四个定位于仓鼠4号染色体的基因座之间的连锁保守性一致。
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