Roy-Byrne P, Post R M, Uhde T W, Porcu T, Davis D
Acta Psychiatr Scand Suppl. 1985;317:1-34. doi: 10.1111/j.1600-0447.1985.tb10510.x.
Using data gathered in a naturalistic study of 95 research patients at the NIMH, a retrospective method of documenting the life course of recurrent affective illness is presented, along with a partial prospective validation of this method. In these patients, the severity, frequency, and duration of manic and depressive episodes, as well as their pattern and distribution, are characterized. These variables are examined in different patients subgrouped according to gender and age of onset, polarity, and rapidity of cycling of illness. The findings are compared with data on the life course of affective illness found in studies from the pre-pharmacologic era.
利用在美国国立精神卫生研究所（NIMH）对95名研究患者进行的自然主义研究中收集的数据，本文介绍了一种记录复发性情感障碍病程的回顾性方法，并对该方法进行了部分前瞻性验证。在这些患者中，描述了躁狂和抑郁发作的严重程度、频率和持续时间，以及发作模式和分布情况。根据性别、发病年龄、极性和疾病循环速度对不同患者亚组的这些变量进行了检查。将这些研究结果与药理学时代之前的研究中发现的情感障碍病程数据进行了比较。
