聚焦于用于治疗生殖系统癌症的浆果衍生生物活性化合物的综述

A Review with a Focus on -Berries-Derived Bioactive Compounds for the Treatment of Reproductive Cancers.

作者信息

Alsharairi Naser A

机构信息

Heart, Mind and Body Research Group, Griffith University, Gold Coast, QLD 4222, Australia.

出版信息

Plants (Basel). 2024 Apr 8;13(7):1047. doi: 10.3390/plants13071047.

DOI:10.3390/plants13071047

PMID:38611574

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11013621/

Abstract

Cancers of the reproductive organs, including prostate, bladder, ovarian, and cervical cancers, are considered the most common causes of death in both sexes worldwide. The genus L. (Ericaceae) comprises fleshy berry crop species, including cranberries, blueberries, lingonberries, bilberries, and bog bilberries, and are widely distributed in many countries. Flavonols, anthocyanins (ACNs), proanthocyanidins (PACs), and phenolic acids are the most bioactive compounds naturally found in berries and have been extensively used as anticancer agents. However, it remains uncertain whether bioactives have a therapeutic role in reproductive cancers (RCs), and how these bioactives could be effective in modulating RC-related signalling pathways/molecular genes. Therefore, this article aims to review existing evidence in the PubMed/MEDLINE database on berries' major bioactive compounds in RC treatment and unravel the mechanisms underlying this process.

摘要

生殖器官癌症，包括前列腺癌、膀胱癌、卵巢癌和宫颈癌，被认为是全球男女最常见的死因。越橘属（杜鹃花科）包括肉质浆果作物物种，如蔓越莓、蓝莓、越橘、欧洲越橘和矮越橘，广泛分布于许多国家。黄酮醇、花青素（ACNs）、原花青素（PACs）和酚酸是浆果中天然存在的最具生物活性的化合物，并已被广泛用作抗癌剂。然而，生物活性物质在生殖系统癌症（RCs）中是否具有治疗作用，以及这些生物活性物质如何有效调节与RC相关的信号通路/分子基因，仍不确定。因此，本文旨在综述PubMed/MEDLINE数据库中关于浆果主要生物活性化合物在RC治疗中的现有证据，并揭示这一过程的潜在机制。