Alsharairi Naser A
Heart, Mind and Body Research Group, Griffith University, Gold Coast, QLD 4222, Australia.
Plants (Basel). 2024 Jan 5;13(2):153. doi: 10.3390/plants13020153.
Breast cancer (BC) is the largest contributor to cancer deaths in women worldwide. Various parts of plants, including fruits, are known for their therapeutic properties and are used in traditional medicine. Fruit species exhibit anticancer activities due to the presence of bioactive natural compounds such as flavonoids and carotenoids. The spp. are fleshy berry-like drupes and are rich in bioactive compounds, with flavonols, flavanols, chalcones, and phenolic acids as the major groups of compounds. While there is clear evidence linking berries with a decreased risk of BC both in in vivo and in vitro experiments, the exact mechanisms involved in the protective effects of spp. rich extracts on BC cells are not fully understood. Thus, the purpose of this review is to highlight the mechanisms of action involved in the therapeutic potential of berries against BC in experimental models.
乳腺癌（BC）是全球女性癌症死亡的最大原因。植物的各个部分，包括果实，因其治疗特性而闻名，并被用于传统医学。由于存在黄酮类化合物和类胡萝卜素等生物活性天然化合物，果实种类具有抗癌活性。该物种是肉质浆果状核果，富含生物活性化合物，黄酮醇、黄烷醇、查耳酮和酚酸是主要的化合物类别。虽然在体内和体外实验中都有明确证据表明该浆果与降低乳腺癌风险有关，但富含该物种提取物对乳腺癌细胞的保护作用的确切机制尚未完全了解。因此，本综述的目的是强调在实验模型中该浆果对乳腺癌治疗潜力所涉及的作用机制。
