Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
Department of Biology, University of Western Ontario, London, ON N6A 5B7, Canada.
Int J Mol Sci. 2024 Mar 26;25(7):3675. doi: 10.3390/ijms25073675.
Mites are highly prevalent arthropods that infest diverse ecological niches globally. Approximately 55,000 species of mites have been identified but many more are yet to be discovered. Of the ones we do know about, most go unnoticed by humans and animals. However, there are several species from the Acariformes superorder that exert a significant impact on global human health. House dust mites are a major source of inhaled allergens, affecting 10-20% of the world's population; storage mites also cause a significant allergy in susceptible individuals; chiggers are the sole vectors for the bacterium that causes scrub typhus; mites are part of the normal microfauna of humans and their pets, but under certain conditions populations grow out of control and affect the integrity of the integumentary system; and scabies mites cause one of the most common dermatological diseases worldwide. On the other hand, recent genome sequences of mites provide novel tools for mite control and the development of new biomaterial with applications in biomedicine. Despite the palpable disease burden, mites remain understudied in parasitological research. By better understanding mite biology and disease processes, researchers can identify new ways to diagnose, manage, and prevent common mite-induced afflictions. This knowledge can lead to improved clinical outcomes and reduced disease burden from these remarkably widespread yet understudied creatures.
螨是高度流行的节肢动物,广泛存在于各种生态环境中。全球已鉴定出约 55000 种螨,但还有更多的螨尚未被发现。在我们已知的螨中,大多数对人类和动物来说是不易察觉的。然而,有几个来自节肢动物超目的螨种对全球人类健康有重大影响。屋尘螨是吸入性过敏原的主要来源,影响全球 10-20%的人口;仓储螨也会导致易感人群产生严重过敏;恙螨是唯一传播引起恙虫病的细菌的媒介;螨是人类及其宠物正常微生境的一部分,但在某些条件下,种群会失控并影响皮肤系统的完整性;疥螨会导致全球最常见的皮肤病之一。另一方面,螨的最新基因组序列为螨的控制和新生物材料的开发提供了新的工具,这些材料可应用于生物医学领域。尽管螨类疾病负担明显,但在寄生虫学研究中它们的研究仍然不足。通过更好地了解螨的生物学和疾病过程,研究人员可以找到新的方法来诊断、管理和预防常见的螨类引起的疾病。这些知识可以改善这些广泛存在但研究不足的生物引起的临床结果并减轻疾病负担。