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影响口服化疗患者药物依从性的因素:一项描述性研究。

Factors affecting medication adherence in patients using oral chemotherapy: A descriptive study.

作者信息

Unal Eda, Cinar Fatma Ilknur, Porucu Canan

机构信息

Faculty of Health Sciences, Kırşehir Ahi Evran University, Kırşehir, Bağbaşı, Turkey.

University of Health Sciences Turkey, Gülhane Faculty of Nursing, Ankara, Turkey.

出版信息

J Oncol Pharm Pract. 2025 Apr;31(3):412-421. doi: 10.1177/10781552241241059. Epub 2024 Apr 13.

DOI:10.1177/10781552241241059
PMID:38613321
Abstract

IntroductionThe utilization of oral chemotherapy agents for cancer treatment has witnessed a steady rise in recent years. The pivotal determinant for the success of oral chemotherapy lies in the adherence of cancer patients to the prescribed treatment. This study aims to explore oral chemotherapy adherence and identify factors influencing medication adherence among cancer patients.MethodsA total of 103 cancer patients participated in this descriptive study. Data were collected using the Oral Chemotherapy Adherence Scale, the Turkish Translation of the Beliefs about Medicines Questionnaire (BMQ-T) and The Functional Living Index-Cancer.ResultsOf the participants, 66% reported good adherence to oral chemotherapy. Key findings indicate that access to health services (β = -1.473,  = 0.009), cancer stage (β = -1.570,  = 0.015) and the BMQ-T subscale of General Overuse (β = .696,  = 0.041) were independent predictors of medication adherence.ConclusionThe study observed medication non-adherence in one-third of patients undergoing oral chemotherapy. Primary contributors to non-adherence included difficulties in accessing health services, advanced cancer stage and the belief that drugs are over-recommended by doctors. These results underscore the need for a heightened focus on preventable factors, such as improving access to health services and addressing beliefs about drug overuse, to enhance medication adherence in patients receiving oral chemotherapy.

摘要

引言

近年来,口服化疗药物在癌症治疗中的应用呈稳步上升趋势。口服化疗成功的关键决定因素在于癌症患者对规定治疗的依从性。本研究旨在探讨口服化疗的依从性,并确定影响癌症患者药物依从性的因素。

方法

共有103名癌症患者参与了这项描述性研究。使用口服化疗依从性量表、《药物信念问卷》土耳其语译本(BMQ-T)和癌症功能生活指数收集数据。

结果

在参与者中,66%报告对口服化疗有良好的依从性。主要研究结果表明,获得医疗服务的机会(β = -1.473,P = 0.009)、癌症分期(β = -1.570,P = 0.015)以及BMQ-T一般过度使用分量表(β = 0.696,P = 0.041)是药物依从性的独立预测因素。

结论

该研究观察到三分之一接受口服化疗的患者存在药物不依从情况。不依从的主要因素包括获得医疗服务困难、癌症晚期以及认为医生过度推荐药物。这些结果强调需要更加关注可预防因素,如改善获得医疗服务的机会和解决对药物过度使用的看法,以提高接受口服化疗患者的药物依从性。

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