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一例盆腔肾误诊致死病例报告

A fatal misdiagnosis of page kidney - case report.

作者信息

Kumarasinghe Gayan, Sivasubramanium Murugupillai, Ekanayake Kasun Bandara, Rambukwella Dhanushka, Sanjaya Bandarage

机构信息

Department of Forensic Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Office of the Judicial Medical Officer, National Hospital, Kandy, Sri Lanka.

出版信息

Forensic Sci Med Pathol. 2024 Dec;20(4):1553-1557. doi: 10.1007/s12024-024-00807-6. Epub 2024 Apr 13.

Abstract

Page kidney is a condition where external compression of the renal artery and renal parenchyma leads to subsequent ischaemia and activation of renin-angiotensin-aldosterone axis. A 42-year-old female with hirsutism, hypertension and diabetes was diagnosed with a right adrenal mass and underwent laparoscopic adrenalectomy. Her hypertension worsened postoperatively and was managed medically. Subsequently she developed a right flank pain on the fifth postoperative day and died suddenly the next day. Autopsy revealed a pale body with cushingoid appearance. Surgical scars were healthy. Internal examination of the abdomen revealed a haemoperitoneum of 500 ml together with a large subcapsular haematoma measuring 1000 ml surrounding the right kidney, compressing the right renal artery. Kidneys were pale and the right kidney was soft and friable. Cortical surface of the right kidney demonstrated a possible surgical puncture site with an overlying thrombus together with a contused inferior vena cava. Other organs were pale but appeared otherwise normal. Histology revealed diffuse cortical necrosis of right kidney and features of adult respiratory distress syndrome in the lungs. Haemorrhagic shock following laparoscopic adrenalectomy for right adrenal tumor was declared as the cause of death, contributed by the development of the Page kidney. Trauma of several aetiologies including laparoscopic abdominal surgery may contribute to Page kidney. It presents with flank pain, hypertension and renal mass. Since postoperative blood loss usually manifests as hypotension, resulting hypertension may mislead the attending clinicians. Once diagnosed, it can be managed with surgical drainage and antihypertensives.

摘要

佩奇肾是一种因肾动脉和肾实质受到外部压迫,继而导致局部缺血并激活肾素 - 血管紧张素 - 醛固酮轴的病症。一名42岁患有多毛症、高血压和糖尿病的女性被诊断出右侧肾上腺肿物,并接受了腹腔镜肾上腺切除术。术后她的高血压病情恶化,接受了药物治疗。随后,她在术后第五天出现右侧胁腹疼痛,并于次日突然死亡。尸检发现尸体面色苍白,呈库欣样外观。手术切口愈合良好。腹部内部检查发现腹腔内有500毫升积血,同时右肾周围有一个1000毫升的巨大包膜下血肿,压迫右肾动脉。双肾均呈苍白状,右肾质地柔软且脆弱。右肾皮质表面可见一个可能的手术穿刺点,其上覆有血栓,同时下腔静脉有挫伤。其他器官虽呈苍白状,但外观未见异常。组织学检查显示右肾弥漫性皮质坏死,肺部有成人呼吸窘迫综合征的特征。因右侧肾上腺肿瘤行腹腔镜肾上腺切除术后发生出血性休克,被认定为死亡原因,佩奇肾的发展也对此有推动作用。包括腹腔镜腹部手术在内的多种病因所致的创伤都可能引发佩奇肾。其症状表现为胁腹疼痛、高血压和肾肿物。由于术后失血通常表现为低血压,因此由此引发的高血压可能会误导主治医生。一旦确诊,可通过手术引流和使用降压药进行治疗。

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