School of Public Health, Capital Medical University, Beijing 100069, China.
Yanjing Medical College, Capital Medical University, Beijing 101300, China.
Environ Toxicol Pharmacol. 2024 Jun;108:104448. doi: 10.1016/j.etap.2024.104448. Epub 2024 Apr 12.
UV irradiation significantly alters nanoplastics (NPs) physicochemical properties, thus affecting their biological toxicity. This study is the first to assess the influence of virgin and UV-aged polystyrene NPs (v-PS NPs, a-PS NPs) on the intestinal barrier of ICR mice. We found that a-PS NPs can cause more severe intestinal barrier damage compared with v-PS NPs. The reason may be attributed to that a-PS NPs produced more ROS in intestinal tissue. Moreover, the strong oxidizing property of hydroxyl radicals (·OH) generated from the a-PS NPs can damage cell membranes through lipid peroxidation, thereby leading to a low clearance rate of ·OH due to the impaired intestinal tissue function, in turn, causing more ROS to accumulate and inducing severe oxidative damage. This research underscores the crucial role of ·OH in mediating oxidative damage from UV-aged nanoparticles, emphasizing the need to consider environmental factors in assessing NPs toxicity.
紫外辐照显著改变纳米塑料（NPs）的物理化学性质，从而影响其生物毒性。本研究首次评估了原始和紫外老化聚苯乙烯 NPs（v-PS NPs、a-PS NPs）对 ICR 小鼠肠道屏障的影响。我们发现 a-PS NPs 比 v-PS NPs 能引起更严重的肠道屏障损伤。原因可能是 a-PS NPs 在肠道组织中产生更多的 ROS。此外，a-PS NPs 产生的羟基自由基（·OH）的强氧化性可以通过脂质过氧化破坏细胞膜，从而导致由于肠道组织功能受损而导致·OH 的清除率降低，反过来又导致更多的 ROS 积累并诱导严重的氧化损伤。这项研究强调了·OH 在介导紫外老化纳米颗粒引起的氧化损伤中的关键作用，强调在评估 NPs 毒性时需要考虑环境因素。
