Chen Han, Yu Longgang, Wang Lin, Zhang Jisheng, Yan Xudong, Jiang Yan
Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Int J Infect Dis. 2024 Jul;144:107054. doi: 10.1016/j.ijid.2024.107054. Epub 2024 Apr 12.
To identify the demographic characteristics and potential risk factors of invasive fungal sinusitis (IFS) patients with Coronavirus Disease in 2019 (COVID-19).
Web of Science, Embase, the Cochrane Library, and PubMed were searched from database inception to August 2023 using the combination of medical searching heading terms "invasive fungal sinusitis" and "COVID-19" and their free words. The research protocol was registered on PROSPERO (CRD42023467175).
A total of 53 studies were included. The mean age of IFS patients with COVID-19 was 53.72 (95% credible interval [CI]: 51.08, 56.36), with 66% males (95% CI: 0.62, 0.70), and 81% diabetes (95% CI: 0.77, 0.86). The mean time from COVID-19 diagnosis to IFS onset was 19.09 days (95% CI: 16.96, 21.22). The percentage of patients with COVID-19 PCR positivity was 33% (95% CI: 0.21, 0.45). Overall, 71% of patients receiving steroid therapy during COVID-19 infection (95% CI: 0.63, 0.78). The odds ratio of diabetes mellitus, steroid administration, and COVID-19 PCR positivity were 6.09, 2.21, and 1.82, respectively. COVID-19 infection did not affect the IFS stage.
IFS patients with COVID-19 had an average age of 53.72 years and were predominantly males, with a mean interval of 19.09 days from COVID-19 diagnosis to IFS onset. Diabetes, steroid administration, and COVID-19 PCR positivity were risk factors.
确定2019年冠状病毒病（COVID-19）侵袭性真菌性鼻窦炎（IFS）患者的人口统计学特征和潜在危险因素。
从数据库建立至2023年8月，使用医学检索主题词“侵袭性真菌性鼻窦炎”和“COVID-19”及其自由词组合，检索Web of Science、Embase、Cochrane图书馆和PubMed。研究方案已在PROSPERO（CRD42023467175）上注册。
共纳入53项研究。COVID-19合并IFS患者的平均年龄为53.72岁（95%可信区间[CI]：51.08，56.36），男性占66%（95%CI：0.62，0.70），糖尿病患者占81%（95%CI：0.77，0.86）。从COVID-19诊断到IFS发病的平均时间为19.09天（95%CI：16.96，21.22）。COVID-19 PCR阳性患者的比例为33%（95%CI：0.21，0.45）。总体而言，71%的患者在COVID-19感染期间接受了类固醇治疗（95%CI：0.63，0.78）。糖尿病、类固醇给药和COVID-19 PCR阳性的比值比分别为6.09、2.21和1.82。COVID-19感染不影响IFS分期。
COVID-19合并IFS患者的平均年龄为53.72岁，以男性为主，从COVID-19诊断到IFS发病的平均间隔为19.09天。糖尿病、类固醇给药和COVID-19 PCR阳性是危险因素。
