Department of Medicine, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil.
Department of Medicine, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil.
Blood Rev. 2024 Jul;66:101197. doi: 10.1016/j.blre.2024.101197. Epub 2024 Apr 9.
When de-novo immune-mediated thrombotic thrombocytopenic purpura (TTP) is diagnosed following an invasive procedure, clinical presentation patterns and outcomes are poorly defined. Therefore, in a systematic literature review of patients diagnosed with TTP following an invasive surgical or non-surgical procedure, we identified 19 studies reporting data on 25 patients. These data suggest that 1) TTP pathogenesis likely begins prior to the invasive procedure, 2) patients experience significant diagnostic delays, and 3) there is a high incidence of renal replacement therapy. Although invasive procedures may trigger TTP, further studies are needed to clarify the mechanisms underlying this association.
当侵袭性操作后新发免疫介导性血栓性血小板减少性紫癜（TTP）被诊断时，其临床表现模式和结局尚未明确。因此，我们对诊断为侵袭性手术或非手术操作后 TTP 的患者进行了系统文献回顾，共纳入 19 项研究，报道了 25 例患者的数据。这些数据提示：1）TTP 的发病机制可能在侵袭性操作之前开始；2）患者存在显著的诊断延迟；3）肾脏替代治疗的发生率较高。虽然侵袭性操作可能引发 TTP，但仍需要进一步研究以阐明其发病机制。
